ET-blockade and Exercise-induced Vascular Adaptations in T2DM

Effect of a Dual ET(Endothelin)-Blocker on Exercise Induced Vascular Adaptations in Type 2 Diabetes Mellitus (T2DM)

The purpose of this study is to establish the effect of ET blockade on vascular adaptations during an 8-week exercise program in subjects with T2DM. We hypothesize that combining ET - blockade with exercise training leads to an acute increase of exercise induced blood flow when compared with exercise alone. We expect that this will lead to an optimization of vascular training effect in T2DM.

Inclusion Criteria:

• Type 2 Diabetes Mellitus (>2 years since diagnosis) OR controls

Exclusion Criteria:

• <40 years of age
• >65 years of age
• smoking
• cardiovascular disease
• diabetes related manifest vascular complications
• Type 1 Diabetes Mellitus
• use of Glibenclamide
• use of HIV drugs
• use of calcineurin inhibitors
• use of drugs that interfere with CYP3A4 and CYP2C19