Human epidermalgrowth factor receptor-2(HER2) negative Luminal B subtype breast cancer patients are included. After 4 cycles of Capecitabine combined with Docetaxel(XT) protocol neoadjuvant chemotherapy ,those who reach partial response(PR) but not pathological complete response(pCR) are randomly divided into the group treated with XT protocol and the group with Capecitabine combined with Epirubicin and Cyclophosphamide(XEC) protocol ,then compare the disease free survival(DFS) and overall survival(OS) of two subgroup.

Individualized treatment of breast cancer has become one of the main directions in the clinical and research areas of breast cancer,and the individualized treatment of the estrogen receptor(ER) positive patients which covered 65% of total cases is of vital importance. Historical research showed that among the ER-positive and HER2-negative breast cancer,Luminal B breast cancer with Ki67>14% is more likely to be benefited from chemotherapy,compared with the Luminal A breast cancer with Ki67<14%. And the results of our previous research showed that, the neoadjuvant XT protocol has more than 17% pCR rate in Luminal B subtype breast cancer.However,to those who didn't reach pCR,we've got no evidence whether switching to Anthracycline-based post operative protocol can benefit them.So that,we sketch out a randomized controlled multicentric phase III clinical trail.HER2 negative Luminal B subtype breast cancer patients are included. After 4 cycles of XT protocol neoadjuvant chemotherapy ,those who reach PR but not pCR are randomly divided into the group treated with XT protocol and the group with XEC protocol ,then compare the DFS and OS of two subgroup.

Inclusion Criteria:

• Chinese population surgery patients with invasive breast cancer；
• Stage II-III；
• ER positive；
• HER2 negative；
• Ki67≥14%；
• Aged between 18 and 70 years old；
• The maximum diameter of the primary tumor greater than 1cm；
• ECOG score 0-1 points； -Have adequate baseline bone marrow and organ function reserve : absolute neutrophil count ≥ 1500/mm3, platelet count ≥ 8g/dl; the ≥ 100000/mm3 hemoglobin concentration and serum creatinine ≤ 1.5 times the upper limit of normal ; aspartate aminotransferase and alanine aminotransferase ≤ 2.5 times the upper limit of normal , bilirubin ≤ 1.5 times the upper limit of normal ; left ventricular ejection fraction ( LVEF ) ≥ 50%

Exclusion Criteria: - Non - Chinese population of patients；

• Non- invasive cancer patients;
• Inflammatory Breast Cancer patients;
• Metastatic breast cancer patients;
• HER2 positive patients;
• Ki67<14% patients;
• No adequateBaseline bone marrow or organ function reserve;
• ECOG PS score ≥ 2 points;
• Younger than 18 years of age or greater than 70 years old;
• Already accepted therapy including chemotherapy , endocrine therapy or targeted therapy before neoadjuvant treatment;
• HER2-positive patients with left ventricular ejection fraction less than 55 % can not receiving Herceptin;
• Known allergy of docetaxel , capecitabine , epirubicin , ring phosphonamide .

HER2 negative Luminal B subtype breast cancer patients