The Role of Mid-Life Adiposity in Functional Brain Connectivity

The Role of Mid-Life Adiposity in Functional Brain Connectivity

The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.

Participants will have one visit for:

• Blood draw
• Body composition scan
• Cognitive screen
• Neurological exam
• MRI scan

The visit will take approximately 3 hours.

Inclusion Criteria:

• 45-65 years of age
• Normal memory
• Right-handed
• General good physical health

Exclusion Criteria:

• History of stroke or neurological disease
• Seizures or head injury with loss of consciousness within the last five years
• Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
• Claustrophobia

More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.