Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Dole Food Company | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Nutrasorb is a newly developed food product (see www.nutrasorb.com). This study will use the Nutrasorb soy protein product that is matrixed with polyphenols from blueberries and green tea extract, and test for efficacy as a nutritional countermeasure to exercise-induced physiologic stress (i.e., immune dysfunction, inflammation, and oxidative stress) using both traditional and metabolomics-based outcome measures.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nutrasorb | Experimental | Soy protein powder sorbed with polyphenols from blueberries and green tea extract |
|
| Placebo | Placebo Comparator | Soy protein isolate powder without polyphenols (with food coloring) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nutrasorb | Dietary Supplement | from blueberry and green tea extracts (2,136 mg/d gallic acid equivalents) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Metabolomics; change in metabolites over time | GC-MS and LC-MS through Metabolon | 18-day period; Blood samples collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running |
| Measure | Description | Time Frame |
|---|---|---|
| Change in inflammation | CRP and a cytokine panel | 18-day period; Blood samples collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running |
| Change in oxidative stress |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| David C Nieman, DrPH | Appalachian State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ASU Human Performance Laboratory, North Carolina Research Campus | Kannapolis | North Carolina | 28081 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23967286 | Derived | Nieman DC, Gillitt ND, Knab AM, Shanely RA, Pappan KL, Jin F, Lila MA. Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: a randomized trial using a metabolomics approach. PLoS One. 2013 Aug 15;8(8):e72215. doi: 10.1371/journal.pone.0072215. eCollection 2013. |
| Label | URL |
|---|---|
| Lab web site | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D007249 | Inflammation |
| D007154 | Immune System Diseases |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Placebo | Dietary Supplement |
|
F2-isoprostanes, protein carbonyls, FRAP, ORAC
| 18-day period; Blood samples collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running |
| Change in immune function | Anti-viral activity using virus-infected HeLa cells | 18-day period; Blood samples collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running |