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A Brillouin ocular analyzer uses a low-power near infrared laser light to probe the viscoelastic properties of the cornea and crystalline lens in the eye. The study hypothesis is that the instrument can measure the Brillouin light scattering spectra from the eye safely and effectively from human subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal Healthy Subjects | Experimental | Brillouin Ocular Analyser |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brillouin Ocular Analyser | Device | Measurement of the local viscoelastic properties (Brillouin Shift) of the Anterior Eye Segment. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with adverse events | Complete standard eye exam including medical and ocular history with manifest refraction, Amsler grid evaluation (macular test), color vision (Ishihara color plates), Scotopic pupil measurement (Colvard pupillometer), Slit lamp biomicroscopy of anterior segment, intraocular pressure measurement, dilated fundoscopic exam (2.5% phenylephrine and 0.5% tropicamide), and corneal topography (Pentacam). | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity and accuracy of Brillouin modulus measurement. | It will be tested if, with the parameters designed for in vivo operation, the Brillouin ocular analyzer is sensitive enough to characterize the elasticity of cornea and crystalline lens as well as its spatial distribution within the ocular tissue. | at time of imaging session |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Seok-Hyun Yun, PhD | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts Eye and Ear Infirmary | Boston | Massachusetts | 02114 | United States | ||
| Massachusetts General Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22513631 | Result | Scarcelli G, Yun SH. In vivo Brillouin optical microscopy of the human eye. Opt Express. 2012 Apr 9;20(8):9197-202. doi: 10.1364/OE.20.009197. |
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| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D011305 | Presbyopia |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D012030 | Refractive Errors |
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| Boston |
| Massachusetts |
| 02114 |
| United States |