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| Name | Class |
|---|---|
| Hellenic Cardiology Society | OTHER |
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This is a multicenter, prospective, observational investigation, focusing of antiplatelet treatment in patients with moderate to high risk acute coronary syndrome (TIMI risk score ≥3)subjected to percutaneous coronary intervention (PCI), being conducted in 7 PCI capable hospitals in Greece. Data concerning patients' demographic, clinical/procedural characteristics and contraindications/special warnings and precautions to P2Y12 inhibitors are collected during initial hospitalization. Study involves 3 follow-up visits after hospital discharge(Day 30, at 6 months and at 12 months) where data on major adverse cardiac events (death, myocardial infarction, stroke, urgent revascularization procedure with PCI or CABG), bleeding events(according to Bleeding Academic Research Consortium criteria)and adherence to antiplatelet treatment are collected.
In patients under ticagrelor or prasugrel treatment, platelet reactivity measurement with VerifyNow assay will be performed at Day 30
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| Measure | Description | Time Frame |
|---|---|---|
| MACES at 12 months following PCI | The composite of death, myocardial infarction, stroke, urgent revascularization procedure with PCI or CABG at 12 months after PCI | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Any bleeding event (BARC classification) at 12 months after PCI | Any bleeding event (BARC classification) at 12 months after PCI | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Rates of P2Y12 inhibitors (Clopidogrel, Prasugrel and Ticagrelor) use at 12 months following PCI | Rates of P2Y12 inhibitors (Clopidogrel, Prasugrel and Ticagrelor) use at 12 months following PCI | 12 months |
| Any bleeding event (BARC classification) at 12 months after PCI |
Inclusion Criteria:
Exclusion Criteria:
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Study population is consisted of patients with acute coronary syndrome subjected to PCI in 6 geographic regions of Greece
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Patras University Hospital | Pátrai | Achaia | 26500 | Greece | ||
| G.Gennimatas General Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26025572 | Derived | Alexopoulos D, Vogiatzi C, Stavrou K, Vlassopoulou N, Perperis A, Pentara I, Xanthopoulou I. Diabetes mellitus and platelet reactivity in patients under prasugrel or ticagrelor treatment: an observational study. Cardiovasc Diabetol. 2015 May 30;14:68. doi: 10.1186/s12933-015-0232-1. | |
| 24990396 | Derived | Alexopoulos D, Stavrou K, Koniari I, Gkizas V, Perperis A, Kontoprias K, Vogiatzi C, Bampouri T, Xanthopoulou I. Ticagrelor vs prasugrel one-month maintenance therapy: impact on platelet reactivity and bleeding events. Thromb Haemost. 2014 Sep 2;112(3):551-7. doi: 10.1160/TH14-02-0119. Epub 2014 Jul 3. |
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Any bleeding event (BARC classification) at 12 months after PCI between lowest and highest quartile of platelet reactivity value at Day 30 |
| 1 year |
| Athens |
| Attica |
| Greece |
| University Hospital, Alexandroupolis | Alexandroupoli | Greece |
| 1st Department of Cardiology, Ippokration Hospital | Athens | Greece |
| Alexandra Hospital, Athens, Greece | Athens | Greece |
| Onassis Cardiac Surgery Center | Athens | Greece |
| University Hospital, Ioannina | Ioannina | Greece |
| Iraklion University Hospital, Iraklion, Greece | Irakleio | Greece |
| Larissa University Hospital | Larissa | Greece |
| 23978364 | Derived | Alexopoulos D, Goudevenos JA, Xanthopoulou I, Deftereos S, Sitafidis G, Kanakakis I, Hamilos M, Parissis H, Ntalas IV, Angelidis C, Petousis S, Vavuranakis M, Hahalis G, Stefanadis C; GRAPE Investigators. Implementation of contemporary oral antiplatelet treatment guidelines in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a report from the GReek AntiPlatelet rEgistry (GRAPE). Int J Cardiol. 2013 Oct 15;168(6):5329-35. doi: 10.1016/j.ijcard.2013.08.007. Epub 2013 Aug 15. |
| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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