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Alzheimer's disease (AD) is the most common neurodegenerative disorder afflicting the elderly. Currently, some biochemical tests performed on Cerebrospinal Fluid (CSF) samples have demonstrated to discriminate to some extend between AD and non-AD individuals based on the levels of tau, phospho-tau or Aβ42. We aim to investigate newly identified proteins whose levels increase during the Braak Stages of AD that are accessible in other body fluids such as blood, urine or saliva. The detection of these proteins would allow performing simple tests in case its levels were confirmed to be associated with the AD pathology.
We do not desire to provide a more extensive description
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AD patients | Subject fulfilling the McKhann criteria for clinical probable AD | ||
| Healthy elder persons | Healthy controls with abscence of any cognitive disorder |
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| Measure | Description | Time Frame |
|---|---|---|
| Differences in blood, saliva and urine protein levels in patients with Alzheimer's Disease versus healthy controls. | Protein levels will be measured by classical immunoblotting blot analysis and quantified; Classical statistical analyses will be performed in order to detect any significant differences. | Up to 1 year |
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Inclusion Criteria:
- mild to moderate AD
Exclusion Criteria:
-
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Persons with Alzheimer's disease
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jos Tournoy | Contact | +3216342640 | jos.tournoy@uzleuven.be |
| Name | Affiliation | Role |
|---|---|---|
| Bart De Strooper | KU Leuven | Principal Investigator |
| Francesc Guix | KU Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UZ Leuven | Recruiting | Leuven | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19056867 | Background | Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA. Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol. 2009 Feb;20(2):363-79. doi: 10.1681/ASN.2008040406. Epub 2008 Dec 3. |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Urine, blood and saliva in Biobank
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |