The Effects of Weight Reduction in IgA Nephropathy

The Effects of Weight Reduction in Chronic Proteinuric IgA Nephropathy

The study aims to explore the non-pharmacological treatment of IgA nephropathy by weight reduction. The investigators hypothesized that benefits of weight loss may reduce proteinuria.

This is a prospective randomized study in adult IgA nephropathy. The investigators enrolled 30 patients who have proteinuria exceeds 1 g per day with biopsy proven IgA nephropathy. The experimental arm recieves the non-pharmacological treatment, weight reduction protocol. All patients in this arm must be reduce their body weight in 3-5 % from baseline as protocol. Another arm is control group which recieves standard treatment of IgA nephropathy including ACEIs/ARBs for blood pressure control (target < 130/80 mmHg). The primary outcome is proteinuria level. The secondary outcome is cytokines and inflammatory markers level including interleukin-6, resistin, adiponectin, leptin and monocyte chemoattractant protein-1.

Inclusion Criteria:

• Biopsy-proven IgA nephropathy
• body mass index more than 23 Kg/m2
• 24 hours urine protein more than 1 g
• estimated GFR more than 20 ml/min

Exclusion Criteria:

• pregnancy and lactation
• rapidly renal function decline
• crescent formation in renal biopsy more than 10%