Ischaemia-réperfusion During the Coronary Surgery With Beating Heart

Effects of Diltiazem and/or N-Acétylcystéine Versus Placebo on hémodynamiques and Biological Repercussions of the Ischaemia-réperfusion During the Coronary Surgery With Beating Heart

Less oxidative stress occurs during off-pump than on-pump coronary artery bypass graft (CABG) surgery but warm ischaemia-reperfusion injury may occur following transient coronary artery clamping. The aim of this study was to compare the preventive effects of diltiazem and N-acetylcysteine (NAC), alone or in combination, on biomarkers of myocardial damage and oxidative stress during off-pump CABG surgery.

Inclusion Criteria:

• Age included between 60 and 80 years

Exclusion Criteria:

• Age < 60 or > 80 years
• Pregnancy
• The allergy in used medicines (N-acétylcystéine, Diltiazem)
• Presence of a pathology valvulaire associated
• Urgency
• Unstable angor
• Bypass as a matter of urgency
• Recours peropératoire to a CEC
• FE < 0,40
• BAV of the 2nd and 3rd not sailed degree
• fibrillation or flutter little finger.