Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The advent of highly active antiretroviral treatment has resulted in the survival into adolescence of an increasing proportion of infants and children with perinatal HIV infection in Senegal. However, the transformation of HIV into a chronic disease needing lifelong antiretroviral treatment (ART) raises new challenges, among others related to a disturbance of glucose metabolism, lipid abnormalities, in addition to the potential effects on children's growth and puberty. Little is known on nutritional and metabolic changes in HIV-infected children on ART in Africa, while implementation of the latest WHO recommendations should eventually lead to an increase in the number of children on ART in this region. Moreover, bio-clinical evolution of untreated children is poorly documented in the African context. It therefore urgently needed to institute a cohort study to evaluate, in the long term, the impact of HIV infection and/or ART on nutritional and metabolic disorders and to characterize the risk factors of their occurrence in children and adolescents infected as they move through adolescent into adulthood.
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of delayed growth | Delayed growth is defined by height for age < -2 z-scores, wasting (%) by weight-for height < -2 z-scores and/or BMI-age < -2 z-scores | Baseline |
| Prevalence of delayed puberty | Delayed puberty is assessed by age of entry into puberty and the age of transition to different Tanner staging | Baseline |
| Prevalence of lipodystrophy | Lipodystrophy (lipoatrophy, lipohypertrophy, combined forms) is defined by direct observation and by joint analysis of anthropometric measures associated with fat tissue index and lean tissue index measured by electrical bio-impedancemetry | Baseline |
| Prevalence of blood lipids ans glucose abnormalities | Measurement of blood glucose, total cholesterol, HDL, LDL and triglycerides | Baseline |
| Incidence of delayed growth | Delayed growth is defined by height for age < -2 z-scores, wasting (%) by weight-for height < -2 z-scores and/or BMI-age < -2 z-scores | Annually for 3 years from the anniversary date of the study |
| Incidence of delayed puberty | Assessed by age of entry into puberty and the age of transition to a different Tanner stage | Annually for 3 years from the anniversary date of the study |
| Incidence of lipodystrophy | defined by direct observation and by joint analysis of anthropometric measures associated with changes in fat tissue index and lean tissue index measured by electrical bio-impedancemetry |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
HIV-1 infected individuals age between 2 ans 16 years
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Philippe Msellati, MD | IRD : French Research Institute for Development | Principal Investigator |
| Haby Sy Signate, MD | Hôpital d'Enfant Albert Royer, Dakar, Senegal | Principal Investigator |
| Ngagne Mbaye, MD | Hôpital Roi Baudoin, Guédiawaye, Senegal | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital d'enfant Albert Royer | Dakar | Senegal | ||||
| Hôpital Roi Baudoin |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30081838 | Derived | Cames C, Pascal L, Ba A, Mbodj H, Ouattara B, Diallo NF, Msellati P, Mbaye N, Sy Signate H, Blanche S, Diack A; MAGGSEN Cohort Study Group. Low prevalence of lipodystrophy in HIV-infected Senegalese children on long-term antiretroviral treatment: the ANRS 12279 MAGGSEN Pediatric Cohort Study. BMC Infect Dis. 2018 Aug 6;18(1):374. doi: 10.1186/s12879-018-3282-7. | |
| 27881690 |
| Label | URL |
|---|---|
| Sponsor website | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D008060 | Lipodystrophy |
| ID | Term |
|---|---|
| D012875 | Skin Diseases, Metabolic |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D052439 | Lipid Metabolism Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided
Plasma, blood cells and urine samples to be retained
| Annually for 3 years from the anniversary date of the study |
| Incidence of blood lipid and glucose abnormalities | Repeated measurement of blood glucose, total cholesterol, HDL, LDL and triglycerides | Annually for 3 years from the anniversary date of the study |
| Guédiawaye |
| Senegal |
| Cames C, Varloteaux M, Have NN, Diom AB, Msellati P, Mbaye N, Mbodj H, Sy Signate H, Diack A; ANRS 12279 MAGGSEN Cohort Study Group. Acceptability of Outpatient Ready-To-Use Food-Based Protocols in HIV-Infected Senegalese Children and Adolescents Within the MAGGSEN Cohort Study. Food Nutr Bull. 2017 Mar;38(1):27-36. doi: 10.1177/0379572116679053. Epub 2016 Nov 23. |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |