This randomized clinical study investigates the efficiency of plasma rich in growth factors (PRGF-Endoret) in combination with bone grafts in the healing of bone and soft tissues after the performance of lateral sinus floor elevation.

The hypothesis of this study is that the use of PRGF-Endoret will produce similar bone formation regardless the type of bone graft.

Inclusion Criteria:

• Patients over 18 years
• Patients requiring implant prostheses oral rehabilitation.
• Patients with insufficient residual height in posterior maxilla requiring a sinus lift procedure to insert the implants

Exclusion Criteria:

• Not having complete the informed consent form.
• Sinusitis.
• Alcoholism.
• Suffering severe haematological disorder or disease.
• Be undergoing or having received radiotherapy, chemotherapy or immunosuppressive therapy, corticosteroids and / or anticoagulants, 30 days prior to the study inclusion.
• In usual treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or other anti-inflammatory drugs.
• Background of chronic hepatitis or liver cirrhosis.
• Diabetes mellitus with poor metabolic control (glycosylated hemoglobin above 9%)
• Patients undergoing dialysis.
• Presence of malignant tumors, hemangiomas or angiomas in the extraction area.
• History of ischemic heart disease in the last year.
• Pregnancy or intention to become pregnant during the study follow-up period.
• Metabolic bone disease
• Patients taking bisphosphonates drugs both orally and intravenously.
• In general, any inability to participate in the study