POLARIS : A non-interventional study in patients with diabetic macular edema (DME) with central involvement to assess the effectiveness of existing anti-vascular endothelial growth factor (anti-VEGF) treatment regimens.

Inclusion Criteria:

• Patients diagnosed with type 1 or 2 diabetes mellitus
• Patients diagnosed with DME with central involvement (defined as the area of the center subfield of optical coherence tomography [OCT])
• Patients for whom the decision has been made to treat with an approved anti-VEGF therapy prior to inclusion into the study
• Patients who received the first approved intravitreal anti VEGF treatment from October 01, 2012
• Patients who give informed consent in writing for study participation

Exclusion Criteria:

• Treatment with any anti-VEGF therapy prior to the start of the observation period (October 01, 2012) or enrolment into the study
• Participation in an investigational program with interventions out of clinical routine practice

In- and outpatients at participating sites with a diagnosis of DME with central involvement. Patients will be enrolled after the decision for treatment with an approved anti-VEGF therapy has been made at or after October 2012 by the study physician.