Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2008-A01162-53 | Other Identifier | ID RCB |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism
Analysis about 50 genes in glutamate synapse
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Autism | Experimental | Analysis of the glutamate synapse in autism |
|
| Relative | Other | Analysis of the glutamate synapse in autism |
|
| Major control | Other | DNA collection |
|
| Minor control | Other | auditory evoked potentials |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| analysis of the glutamate synapse in autism | Genetic | Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism |
|
| Measure | Description | Time Frame |
|---|---|---|
| screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients | two years |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Frédérique BONNET-BRILHAULT, MD PHD | University François Rabelais of TOURS | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU - Centre de Ressources Autisme (CRA) | Brest | 29000 | France | |||
| CHS du ROUVRAY |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26055424 | Result | Bonnet-Brilhault F, Alirol S, Blanc R, Bazaud S, Marouillat S, Thepault RA, Andres CR, Lemonnier E, Barthelemy C, Raynaud M, Toutain A, Gomot M, Laumonnier F. GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explorations distinguish autism from intellectual disability. Mol Psychiatry. 2016 Mar;21(3):411-8. doi: 10.1038/mp.2015.75. Epub 2015 Jun 9. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D001321 | Autistic Disorder |
| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
| ID | Term |
|---|---|
| D005072 | Evoked Potentials, Auditory |
| ID | Term |
|---|---|
| D005071 | Evoked Potentials |
| D000071080 | Cortical Excitability |
| D055724 | Electrophysiological Phenomena |
| D010829 | Physiological Phenomena |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| DNA collection | Genetic | DNA collection |
|
| Auditory evoked potentials | Other | auditory evoked potentials |
|
| Rouen |
| 76000 |
| France |
| Chru - Cic | Tours | 37000 | France |
| CHRU - Pédopsychiatrie | Tours | F-37000 | France |
| D000084323 | Vestibulocochlear Physiological Phenomena |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |