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| Name | Class |
|---|---|
| Bio-medical Carbon Technology Co., Ltd. | INDUSTRY |
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This study aims to compare the effectiveness of two wound dressings, Acticoat Absorbent (AA) and BCT Antimicrobial (BCT) on Split Thickness Skin Graft (STSG) donor site.
Seventy patients who undergo STSG procedure in Kaohsiung Veterans General Hospital will be recruited. Two donor sites of equal lengths and widths on the same thigh, which are at least 2 cm apart will be covered randomly with AA and BCT each. Wound healing rate and infection rate will be assessed at 7 and 14 days after surgery. Degrees of pain and itchiness will be assessed daily with Visual Analogue Scale for the first 7 post-operative days. Scar appearance will be assessed with Vancouver Scar Scale 1, 3 and 6 months post-operatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acticoat Absorbent | Active Comparator | Acticoat Absorbent wound dressing |
|
| BCT wound dressing | Experimental | wound dressing |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acticoat Absorbent | Device | wound dressing |
| |
| BCT |
| Measure | Description | Time Frame |
|---|---|---|
| wound healing rate | percentage of wound area that has healed at this time | 7 days |
| wound infection rate | 7 days | |
| wound healing rate | percentage of wound area that has healed at this time | 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| scar appearance | 1 month | |
| pain and itchiness | 1day | |
| scar appearance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kuei-Chang Hsu, MD | Contact | +886-7-3422121 | 3073 | kchsu@vghks.gov.tw |
| Name | Affiliation | Role |
|---|---|---|
| Kuei-Chang Hsu, MD | Kaohsiung Veterans General Hospital. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kaohsiung Veterans General Hospital | Recruiting | Kaohsiung City | 81362 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10716354 | Background | Klasen HJ. Historical review of the use of silver in the treatment of burns. I. Early uses. Burns. 2000 Mar;26(2):117-30. doi: 10.1016/s0305-4179(99)00108-4. No abstract available. | |
| 16531870 | Background | Trop M, Novak M, Rodl S, Hellbom B, Kroell W, Goessler W. Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient. J Trauma. 2006 Mar;60(3):648-52. doi: 10.1097/01.ta.0000208126.22089.b6. |
| Label | URL |
|---|---|
| Kaohsiung Veterans General Hospital | View source |
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| ID | Term |
|---|---|
| D014946 | Wound Infection |
| D010146 | Pain |
| D011537 | Pruritus |
| D002921 | Cicatrix |
| ID | Term |
|---|---|
| D007239 | Infections |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Device |
wound dressing |
|
|
| 3 months |
| scar appearance | 6 months |
| pain and itchiness | 2 days |
| pain and itchiness | 3 days |
| pain and itchiness | 4 days |
| pain and itchiness | 5 days |
| pain and itchiness | 6 days |
| pain and itchiness | 7 days |
| 17959313 | Background | Vlachou E, Chipp E, Shale E, Wilson YT, Papini R, Moiemen NS. The safety of nanocrystalline silver dressings on burns: a study of systemic silver absorption. Burns. 2007 Dec;33(8):979-85. doi: 10.1016/j.burns.2007.07.014. Epub 2007 Oct 23. |
| 9848045 | Result | Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil. 1998 Nov-Dec;19(6):531-7. doi: 10.1097/00004630-199811000-00013. |
| 17901734 | Result | Argirova M, Hadjiski O, Victorova A. Acticoat versus Allevyn as a split-thickness skin graft donor-site dressing: a prospective comparative study. Ann Plast Surg. 2007 Oct;59(4):415-22. doi: 10.1097/SAP.0b013e3180312705. |
| 11525858 | Result | Innes ME, Umraw N, Fish JS, Gomez M, Cartotto RC. The use of silver coated dressings on donor site wounds: a prospective, controlled matched pair study. Burns. 2001 Sep;27(6):621-7. doi: 10.1016/s0305-4179(01)00015-8. |
| 17175106 | Result | Huang Y, Li X, Liao Z, Zhang G, Liu Q, Tang J, Peng Y, Liu X, Luo Q. A randomized comparative trial between Acticoat and SD-Ag in the treatment of residual burn wounds, including safety analysis. Burns. 2007 Mar;33(2):161-6. doi: 10.1016/j.burns.2006.06.020. Epub 2006 Dec 18. |
| 20961690 | Result | Moiemen NS, Shale E, Drysdale KJ, Smith G, Wilson YT, Papini R. Acticoat dressings and major burns: systemic silver absorption. Burns. 2011 Feb;37(1):27-35. doi: 10.1016/j.burns.2010.09.006. Epub 2010 Oct 18. |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012877 | Skin Manifestations |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |