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Boys suffer a disproportionately large number of fractures compared to girls (55-60%). This study aims to determine why this is the case by identifying risk factors for wrist fractures. The increase in fracture during childhood and adolescence may be associated with 1) risk-taking behaviour in boys, 2) obesity trends in boys during childhood and adolescence, and/or 3) impaired acquisition of bone strength during childhood and adolescence. Importantly from a knowledge translation perspective, modifiable factors such as behaviour, dietary habits or physical activity in boys may predict fracture.
The investigators will measure 400 children (100 girls and 100 boys who have sustained a fracture; 100 same age and sex friends) across 4 years of growth. This study will assess risk behaviours, diet, physical activity, motor proficiency (i.e., balance and coordination), fat and muscle mass and bone strength to determine if there are, 1) differences in whether all or some of these factors predict fractures in boys compared with girls and, 2) whether these factors track forward similarly in boys compared with girls as children advance through the growth spurt.
The investigators aim to better characterize factors that contribute to fracture in boys and girls and to assess whether such factors track across a four year period. The innovation is to use novel methods and an integrated approach, to measure the influence of risk-taking behaviour, body composition, bone microstructure, motor proficiency, diet and physical activity in one model across growth. This will provide a more comprehensive picture of the key multi-factorial predictors of fracture within- and between-sexes. This essential information will provide the basis for change in public health policy, clinical practice, community programs, and targeted interventions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fracture - Boys | Boys who have sustained a distal radius fracture |
| |
| Fracture - Girls | Girls who have sustained a distal radius fracture |
| |
| Non Fracture - Boys | Boys who have not sustained a distal radius fracture |
| |
| Non Fracture - Girls | Girls who have not sustained a distal radius fracture |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fracture - Boys | Other | Annual measurements of risk taking behaviour, body composition, bone microstructure, balance, diet, and physical activity over 4 years |
|
| Measure | Description | Time Frame |
|---|---|---|
| Characterization of factors that contribute to fractures in boys and girls | The factors include:
| Baseline (<3 months after injury) |
| Measure | Description | Time Frame |
|---|---|---|
| Tracking of Risk Factors | The outcomes will be measured across a 3 year interval (4 years in total) to determine whether factors track similarly in boys compared with girls over time and to assess their continued (or not) contribution to fracture. | 4 years |
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Inclusion Criteria:
Exclusion Criteria:
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Fracture patients will be recruited from the orthopaedic clinic at BC Children's Hospital.
Non-fracture subjects will be recruited from the community
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| Name | Affiliation | Role |
|---|---|---|
| Heather McKay, PhD | Centre for Hip Health and Mobility | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre for Hip Health and Mobility | Vancouver | British Columbia | V5Z 1M9 | Canada | ||
| British Columbia Children's Hospital |
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| ID | Term |
|---|---|
| D050723 | Fractures, Bone |
| D000092503 | Wrist Fractures |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D014954 | Wrist Injuries |
| D001134 | Arm Injuries |
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| Fracture - Girls | Other | Annual measurements of risk taking behaviour, body composition, bone microstructure, balance, diet, and physical activity over 4 years |
|
| Non Fracture - Boys | Other | Annual measurements of risk taking behaviour, body composition, bone microstructure, balance, diet, and physical activity over 4 years |
|
| Non Fracture - Girls | Other | Annual measurements of risk taking behaviour, body composition, bone microstructure, balance, diet, and physical activity over 4 years |
|
| Vancouver |
| British Columbia |
| V6H 3V4 |
| Canada |