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| ID | Type | Description | Link |
|---|---|---|---|
| Study-098 | Other Identifier | University of Erlangen-Nurnberg |
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| Name | Class |
|---|---|
| Klinikum Nürnberg | OTHER |
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A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. The aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies.
Our general study hypothesis is that HIT-resistance exercise significantly impact relevant muscular parameters of the upper leg.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIT-exercise, low repetition range | Experimental | High Intensity Resistance Exercise Training, low repetition range, > 75% 1 Repetition Maximum (1RM) |
|
| HIT-exercise, high repetition range | Experimental | High Intensity Resistance Exercise Training, high repetition range, 60 - <75% 1RM |
|
| HIT-exercise with protein | Experimental | High Intensity Resistance Exercise Training with protein supplementation |
|
| Control | Placebo Comparator | No physical exercise intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HIT-exercise, low repetition range | Other | High Intensity Resistance Exercise Training, low repetition range, > 75% 1RM |
|
| Measure | Description | Time Frame |
|---|---|---|
| fat free Cross Sectional Area (CSA) upper leg | fat free muscle cross sectional area of the upper leg at mid-femur via Quantitative Computed Tomography (QCT) | change from baseline in fat free Cross Sectional Area at 5 months |
| Measure | Description | Time Frame |
|---|---|---|
| CSA upper leg | muscle cross sectional area of the upper leg at mid-femur via QCT | change from baseline in CSA upper leg at 5 months |
| Measure | Description | Time Frame |
|---|---|---|
| intra-abdominal fat mass | intra-abdominal fat mass via Magnetic Resonance Imaging (MRI) | change from baseline in intra-abdominal fat mass at 5 months |
| maximum strength leg press | Maximum dynamic strength of the leg extensors/-flexors |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wolfgang Kemmler, PhD | University of Erlangen-Nürnberg Medical School | Study Director |
| Andreas Wittke, MA | University of Erlangen-Nürnberg Medical School | Principal Investigator |
| Klaus Engelke, PhD | University of Erlangen-Nürnberg Medical School | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Medical Physics, University of Erlangen-Nurnberg | Erlangen | 91052 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33345059 | Derived | Tuttor M, von Stengel S, Kohl M, Lell M, Scharf M, Uder M, Wittke A, Kemmler W. High Intensity Resistance Exercise Training vs. High Intensity (Endurance) Interval Training to Fight Cardiometabolic Risk Factors in Overweight Men 30-50 Years Old. Front Sports Act Living. 2020 Jun 16;2:68. doi: 10.3389/fspor.2020.00068. eCollection 2020. | |
| 29216285 |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D009765 | Obesity |
| D003327 | Coronary Disease |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D011506 | Proteins |
| ID | Term |
|---|---|
| D000602 | Amino Acids, Peptides, and Proteins |
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| HIT-exercise, high repetition range | Other | High Intensity Resistance Exercise Training, high repetition range, 60 - < 75 1RM |
|
| HIT-exercise with protein | Other | High Intensity Resistance Exercise Training, low repetition range, > 75% 1RM and Protein Supplementation |
|
| Control | Other | control group, no intervention, maintenance of physical activity |
|
| change from baseline in maximum strength leg press at 5 months |
| metabolic syndrome score | Metabolic Syndrome Score according to Johnson et al. | change from baseline in metabolic syndrome score at 5 months |
| myocardial mass/enddiastolic volume | change from baseline in myocardial mass/enddiastolic volume at 5 months |
| Scharf M, Oezdemir D, Schmid A, Kemmler W, von Stengel S, May MS, Uder M, Lell MM. Myocardial adaption to HI(R)T in previously untrained men with a randomized, longitudinal cardiac MR imaging study (Physical adaptions in Untrained on Strength and Heart trial, PUSH-trial). PLoS One. 2017 Dec 7;12(12):e0189204. doi: 10.1371/journal.pone.0189204. eCollection 2017. |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |