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Morning-only colonoscopy preparation may improve efficiency by allowing same-day patient preparation and colonoscopy. The aim of the investigators study is to compare the efficacy and tolerability of morning-only Polyethylene Glycol (PEG) to split-dose preparation in hospitalized patients undergoing colonoscopy.
This is a single-center, prospective, endoscopist-blinded study in which hospitalized patients scheduled to undergo diagnostic colonoscopy were randomly assigned to receive one gallon of PEG either the morning of colonoscopy or as a split-dose (evening-morning). The primary end point is efficacy of colonoscopy preparation measured by the Ottawa scale. The investigators pre-specified a non-inferiority margin of 1.5 for the difference in Ottawa scale between arms. Secondary end points are patient compliance and tolerance. N: 120 hospitalized patients scheduled for diagnostic colonoscopy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Morning-only polyethylene glycol | Experimental | One gallon of polyethylene glycol to be taken between 5am and 9am on the day of colonoscopy. |
|
| Split-dose polyethylene glycol | Active Comparator | Half gallon of polyethylene glycol to be taken between 7-9 pm on the day before colonoscopy and the remaining half between 7-9 am on the day of colonoscopy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Split-dose polyethylene glycol | Other | Half gallon of polyethylene glycol to be taken between 7-9 pm on the day before colonoscopy and the remaining half between 7-9 am on the day of colonoscopy |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the efficacy of colonoscopy preparation measured by the Ottawa scale | Colonoscopy was performed by gastroenterology fellows under the supervision of attending physicians and both were blinded to the type of preparation taken by the study patients. Bowel cleansing was evaluated by the Ottawa scale. Scoring of each part of the colon (right, middle and left) was done separately and the total amount of fluid was noted. The scores were then added to calculate the total score out of 14. | Day of procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Patient compliance | Before the patients were taken to the endoscopy suite, they completed a questionnaire, asking the amount of preparation that was taken to evaluate compliance. | Day of procedure |
| Patient tolerance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bashar Attar, MD, PhD | Cook County Health & Hospitals System | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | United States |
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| Morning-only polyethylene glycol | Other | One gallon of polyethylene glycol to be taken between 5am and 9am on the day of colonoscopy |
|
Before the patients were taken to the endoscopy suite, they completed a questionnaire to evaluate tolerance for taking the preparation. Patients were asked about side-effects like nausea, vomiting, abdominal pain and bloating.
| Same day |