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| ID | Type | Description | Link |
|---|---|---|---|
| K24DA023186-06 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Morhpine/Taste acuity | Active Comparator | Taste acuity assessment after 1mg subcutaneous morphine injection |
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| Placebo/Taste acuity | Placebo Comparator | Taste acuity assessment after subcutaneous placebo injection |
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| Morphine4/Taste acuity | Active Comparator | Taste acuity assessment after 4mg subcutaneous morphine injection |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| taste acuity assessment | Behavioral | Quantitative measurement of for tasting detection and recognition thresholds, magnitude of perception and hedonic response. |
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| Measure | Description | Time Frame |
|---|---|---|
| Taste | The primary outcome variable will be the taste acuity profile, which includes the taste detection threshold, recognition threshold, magnitude estimation, and hedonic response. | 3 hours after dose administration |
| Measure | Description | Time Frame |
|---|---|---|
| Calories | The secondary outcome measure will be the amount of calories consumed over a 2 hours period following the drug administration. | 6 hours after dose administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Denis G Antoine, M.D. | Johns Hopkins University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins Bayview Medical Center | Baltimore | Maryland | 21224 | United States |
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| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
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| Recorded meal | Behavioral |
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