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A clinical Study to evaluate the safety and pharmacokinetics/pharmacodynamics(PK/PD) of YH4808 after repeated Oral administration and Postprandial state in healthy volunteers
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sequence 1 | Experimental |
| |
| Sequence 2 | Experimental |
| |
| Sequence 3 | Active Comparator |
| |
| Sequence 4 | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| YH4808 | Drug | Group1
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under the plasma concentration versus time curve of YH4808 | Blood sampling during 0 ~ 24 hrs after administration | |
| Peak plasma concentration of YH4808 | Blood sampling during 0~24 hrs after administration |
| Measure | Description | Time Frame |
|---|---|---|
| Time to reach peak plasma concentration of YH4808 | Blood sampling during 0 ~ 24 hrs after administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Minsoo Park, Ph.D, M.D. | Yonsei University Health System, Severance Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yonsei University Health System(Severance Hospital) | Seoul | Seodaemun-gu,Sinchon-dong | 120-752 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34621707 | Derived | Yoon S, Oh E, Park MS, Jang SB, Byun HM, Park H, Kim H, Kim CO. Comparison of the pharmacokinetics and pharmacodynamics of YH4808 in healthy subjects for defining an appropriate dosing regimen. Transl Clin Pharmacol. 2021 Sep;29(3):150-159. doi: 10.12793/tcp.2021.29.e15. Epub 2021 Sep 17. |
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| ID | Term |
|---|---|
| C000625316 | YH4808 |
| D064098 | Esomeprazole |
| ID | Term |
|---|---|
| D009853 | Omeprazole |
| D053799 | 2-Pyridinylmethylsulfinylbenzimidazoles |
| D013454 | Sulfoxides |
| D013457 | Sulfur Compounds |
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| YH4808 | Drug | Group2
|
|
| YH4808 | Drug | Group3
|
|
|
| YH4808 | Drug | Group 4
|
|
|
| D009930 |
| Organic Chemicals |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |