The objective of this study was to evaluate the safety and immunogenicity of Haemophilus influenzae type b vaccine in different injection site.

A randomized trial was conducted in 680 healthy infants with Hib vaccine of two brands. The different sub-groups were selected randomly based on the plan to inoculate vaccines in the upper arm deltoid or vastus lateralis muscle. The safety and immunogenicity were assessed after three or two doses.

Inclusion Criteria:

• participants were under 1 years old, and were in good healthy
• participants were full-time pregnancy and birth weight were more than 2.5 kg

Exclusion Criteria:

• current infectious fever or acute disease
• a history of hypersensitivity to study vaccine components especially tetanus toxoid
• a history of allergy, autoimmune, convulsions, seizures heredity disease
• a history of Hib vaccination or Hib disease
• a history of congenital deformity, developmental disorders or serious chronic diseases, muscle injection contradiction, and immunosuppressive agents, hormone or immunoglobulin received.