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| ID | Type | Description | Link |
|---|---|---|---|
| Study of embryo morphokinetics | Other Identifier | Bloom IVFand Fertility Centre |
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| Name | Class |
|---|---|
| Padmashree Dr. D. Y. Patil Medical College | OTHER |
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study Arm | Experimental | Subjects would receive recombinant Follicle Stimulating Hormone (rFSH) by S.C. injection 150 - 225 IU/day for 9 days. The embryos of subjects would be cultured by time-lapse imagery technique (embryoscope) and analysis would be done using patients receive rFSH (Gonembryo viewer equipped with latest software. |
|
| Control Arm | Active Comparator | Subjects would receive recombinant Follicle Stimulating Hormone (rFSH) by S.C. injection 150 - 225 IU/day for 9 days. The embryos of subjects would be cultured in conventional culture environment and analysis would be done using established subjective morphological criteria. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| recombinant Follicle Stimulating Hormone (rFSH) | Drug | There are two arms of the study. The Study arm and the Control arm. In each arm, subjects, after randomization, will be stimulated with rFSH 225IU/day. On day 6, Cetrorelix 0.25mg/day to be added till the day of Ovitrell. Thereafter, ovum pick-up and embryo transfer to be done. Six weeks after transfer clinical pregnancy identified which will be the end-point of the study. |
| Measure | Description | Time Frame |
|---|---|---|
| No.of top quality embryos produced in both the arms, study arm and control arm. |
| 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy | Clinical pregnancy will be identified by presence of gestational sac(s) and fetal heart-beat by transvaginal ultrasonography in sixth week after embryo transfer. | 6 weeks after embryo transfer (ET) |
| Measure | Description | Time Frame |
|---|---|---|
| No. of mature M2 oocytes obtained | Mature oocyte identified by presence of polar body, fluffy granulosa cells surrounded by corona radiata. | 2 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hrishikesh D Pai, M.D. | Bloom IVF and Fertility Centre | Principal Investigator |
| Manchi R Bharucha, Ph.D. | Bloom IVF and Fertility Centre | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lilavati Hospital and Research Center, IVF department | Mumbai | Maharashtra | 400050 | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18765009 | Result | Lemmen JG, Agerholm I, Ziebe S. Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes. Reprod Biomed Online. 2008 Sep;17(3):385-91. doi: 10.1016/s1472-6483(10)60222-2. |
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| ID | Term |
|---|---|
| D050497 | Stillbirth |
| D020964 | Embryo Loss |
| D000782 | Aneuploidy |
| ID | Term |
|---|---|
| D005313 | Fetal Death |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D015292 | Glycoprotein Hormones, alpha Subunit |
| C571801 | follitropin alfa |
| C062876 | cetrorelix |
| ID | Term |
|---|---|
| D006063 | Chorionic Gonadotropin |
| D006062 | Gonadotropins |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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|
|
| D003643 | Death |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000022 | Abortion, Spontaneous |
| D002869 | Chromosome Aberrations |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D005640 | Follicle Stimulating Hormone |
| D006065 | Gonadotropins, Pituitary |
| D007986 | Luteinizing Hormone |
| D010908 | Pituitary Hormones, Anterior |
| D010907 | Pituitary Hormones |
| D013972 | Thyrotropin |
| D010926 | Placental Hormones |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |