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In this study, Laser Doppler Flowmetry (LDF), Laser Doppler Imaging (LDI), Orthogonal Polarization Spectral Imaging (OPSI), Nail fold video capillaroscopy (NVC) and Optical Coherence Tomography (OCT) will be used to assess differences in microvascular function and density of oral mucosa and skin in subjects with 1) autoimmune diseases with cutaneous involvement: systemic sclerosis (SSc), morphea, dermatomyositis, cutaneous lupus and vasculitis, 2) sickle cell disease (SCD) and 3) chronic graft-versus-host disease (GVHD) compared to healthy subjects. The microvascular changes will be compared to overall treatment response in patients with scleroderma and chronic GVHD as assessments will be made before and after the patients start treatment for their diseases and determine if these imaging techniques provide valuable and reproducible data when assessing a patient's response to treatment for those diseases. In addition, the application of Acoustic Radiation Force Impulse (ARFI) in determining cutaneous thickness in patients with SSc, GVHD and morphea will be evaluated.
The investigators hypothesize that the vascular and dermal structures are altered in patients with autoimmune disease, SCD and chronic GVHD. In addition, they hypothesize that imaging modalities such as LDF, LDI, OCT, NVC, OPSI and ARFI can quantify such structural alterations and can be used to 1) detect early disease activity, 2) quantify and assess response to therapy and 3) quantify and correlate with overall disease activity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Systemic Sclerosis | Patients with SSc will have imaging studies performed at baseline and at 3, 6, 9, 12, 15, 18, 21 and 24 months. |
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| GVHD | Patients with GVHD will have imaging studies performed at baseline and at 3, 6, 9, 12, 18 and 24 months. |
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| Undergoing HSCT | Patients who are about to undergo HSCT will have imaging studies performed at 1 week pre-transplantation, day 40 and 80 post transplantation and at 3 months, 6 months, 12 months 18 months and 24 months post-transplant. |
| |
| Controls | Healthy Controls and Controls with hematologic and solid organ malignancies and dermatitis will have imaging studies performed at a single point in time. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acoustic Radiation Force Impulse (ARFI) | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Microvascular density in oral mucosa and skin | Microvascular density as evaluated using LDF, LDI, OPSI, OCT, NVC and AFRI, will be compared between subjects with and without disease. | over 24 months |
| Microvascular Perfusion in oral mucosa and skin | Microvascular perfusion as evaluated using LDF, LDI, OPSI, OCT, NVC, and AFRI, will be compared between subjects with and without disease. | over 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patient population at Duke University Medical Center and healthy controls
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| Name | Affiliation | Role |
|---|---|---|
| Keith Sullivan, MD | Duke University | Principal Investigator |
| Adela Cardones, MD | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duke University Medical Center | Durham | North Carolina | 27710 | United States |
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| Sickle cell disease | Patients with SCD will have imaging studies performed at baseline and at 3, 6, 9, 12, 15, 18, 21 and 24 months. |
|
| Cutaneous fibrosing disorder | Patients with active cutaneous fibrosing disorder will have imaging studies performed at a single point in time. |
|
| Laser Doppler Flowmetry (LDF) | Other |
|
| Laser Doppler Perfusion Imaging (LDI) | Other |
|
| Optical Coherence Tomography (OCT) | Other |
|
| Orthogonal Polarization Spectral Imaging (OPSI) | Other |
|
| Nail fold video capillaroscopy (NVC) | Other |
|
| ID | Term |
|---|---|
| D001327 | Autoimmune Diseases |
| D000755 | Anemia, Sickle Cell |
| D000092122 | Bronchiolitis Obliterans Syndrome |
| D012595 | Scleroderma, Systemic |
| D045743 | Scleroderma, Diffuse |
| D012594 | Scleroderma, Localized |
| D003882 | Dermatomyositis |
| D014657 | Vasculitis |
| D006086 | Graft vs Host Disease |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
| D000745 | Anemia, Hemolytic, Congenital |
| D000743 | Anemia, Hemolytic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006453 | Hemoglobinopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D000092124 | Organizing Pneumonia |
| D001989 | Bronchiolitis Obliterans |
| D001988 | Bronchiolitis |
| D001991 | Bronchitis |
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012871 | Skin Diseases |
| D017285 | Polymyositis |
| D009220 | Myositis |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D017078 | Laser-Doppler Flowmetry |
| D041623 | Tomography, Optical Coherence |
| ID | Term |
|---|---|
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012212 | Rheology |
| D008919 | Investigative Techniques |
| D041622 | Tomography, Optical |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D014054 | Tomography |
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