Calorie Restriction With Leucine Supplementation

Calorie Restriction With Leucine Supplementation in Postmenopausal Women

The purpose of this study is to determine whether consuming additional leucine during calorie restriction induced weight loss has beneficial or harmful effects on multi-organ (liver, muscle, adipose tissue) insulin sensitivity, colonocyte proliferation rates, the gut microbiome, muscle mass and function, and bone mineral density in obese, postmenopausal women.

Inclusion Criteria:

• Obese with body mass index (BMI) between 30 and 40 kg/m2
• Postmenopausal
• Sedentary (i.e., less than 1.5 hours of exercise per week)

Exclusion Criteria:

• Individuals with diabetes and/or uncontrolled hypertension
• Individuals with hepatitis B and/or C
• Individuals who smoke
• Individuals with an allergy to whey protein