The purpose of this study is to evaluate pharmacodynamics, safety, tolerability and pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects with Albuminuria and Moderately Decreased GFR

Inclusion Criteria:

• Subjects with Type II diabetic nephropathy, who have been treated with angiotensin converting enzyme-inhibitor (ACE-I) or angiotensin II receptor blocker (ARB)
• Glycosylated haemoglobin (HbA1c) ≤10.5%
• An estimated glomerular filtration rate (eGFR) ≥30-<60 mL/min/1.73m^2
• Subject with albuminuria

Exclusion Criteria:

• History of Type I diabetes, pancreas or β-cell transplantation, or diabetes secondary to pancreatitis or pancreatectomy
• Serum potassium level <3.5 or >5.0 mmol/L
• Subjects who had acute kidney injury (AKI) within 3 months prior to baseline or have undergone renal dialysis at any time prior to randomisation
• Subjects with a history of renal transplant
• Subjects with clinically significant hypotension