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This study is to evaluate the antiviral effect of GS-5806 in healthy adults infected with a strain of Respiratory Syncytial Virus.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GS-5806 | Experimental | GS-5806, powder for oral solution |
|
| Sugar powder for oral solution in juice | Placebo Comparator | Sugar powder for oral solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GS-5806 | Drug | GS-5806, powder for oral solution |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Change in viral load measurements. | Area under the curve for viral load as measured by qRT-PCR assay from the first viral load measurement post initial dose of GS-5806 or placebo through day 12. | Post initial dose of GS-5806/placebo to Day 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Change of baseline symptoms | Change of baseline symptoms post initial dose of GS-5806 or placebo through Day 12 | Innoculation through Day 12 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Adeyi Adeyemi, MD | Retroscreen Virology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Retroscreen Virology | London | E12AX | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25140957 | Derived | DeVincenzo JP, Whitley RJ, Mackman RL, Scaglioni-Weinlich C, Harrison L, Farrell E, McBride S, Lambkin-Williams R, Jordan R, Xin Y, Ramanathan S, O'Riordan T, Lewis SA, Li X, Toback SL, Lin SL, Chien JW. Oral GS-5806 activity in a respiratory syncytial virus challenge study. N Engl J Med. 2014 Aug 21;371(8):711-22. doi: 10.1056/NEJMoa1401184. |
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| ID | Term |
|---|---|
| D018357 | Respiratory Syncytial Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
| ID | Term |
|---|---|
| D018186 | Pneumovirus Infections |
| D018184 | Paramyxoviridae Infections |
| D018701 | Mononegavirales Infections |
| D012327 | RNA Virus Infections |
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| ID | Term |
|---|---|
| C000591241 | presatovir |
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| Drug |
|