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The purpose of the study is 1> to compare neointimal stent coverage after OCT-guided vs. Angio-guided PCI, 2> to compare neointimal stent coverage at 3 months after EES vs BES implantation, 3> to determine the duration of dual antiplatelet therapy by OCT measurement at 3 months
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Angio guided PCI | Active Comparator |
| |
| OCT-guided PCI | Experimental |
| |
| BES | Active Comparator |
| |
| EES | Experimental |
| |
| Keep dual antiplatelet therapy (DAPT) | Active Comparator | Study subjects will be allocated into this arm with non-randomization method |
|
| Discontinue Dual antiplatelet therapy (DAPT) | Active Comparator | Study subjects will be allocated into this arm with non-randomization method |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Angio-guided PCI with EES or BES | Device | Angio-guided intervention |
| |
| Measure | Description | Time Frame |
|---|---|---|
| percentage of neointimal coverage at 3 month-OCT after stent implantation | at 3 month-OCT after stent implantation |
| Measure | Description | Time Frame |
|---|---|---|
| The occurrence of the composite of cardiac death, MI, definite or probable stent thrombosis, and TIMI-defined major bleeding for 12 months | 12 months after PCI | |
| percentage of malposition strut at 3 month-OCT after stent implantation | 3 months after PCI |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine | Seoul | 120-752 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41044734 | Derived | Jin IT, Kim Y, Heo SJ, Lee YJ, Lee SJ, Hong SJ, Ahn CM, Kim JS, Cho DK, Ko YG, Choi D, Hong MK, Kim BK. Comparison of Short-term and Standard Duration Dual Antiplatelet Therapy in Elderly Patients: A Pooled Analysis of Five Korean Randomized Clinical Trials. Korean Circ J. 2025 Dec;55(12):1125-1137. doi: 10.4070/kcj.2025.0093. Epub 2025 Jul 14. | |
| 30562088 |
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| OCT-guided PCI with EES or BES |
| Device |
OCT-guided intervention |
|
| PCI with BES under angio-guide or OCT guide | Device | biolimus A9-eluting stent. |
|
| PCI with EES under angio-guide or OCT guide | Device | everolimus eluting stent. |
|
| Keep DAPT | Drug | maintain DAPT for 12 months according to level of uncovered strut (>6%) at 3months OCT follow up after stent implantation. |
|
| Discontinue DAPT | Drug | discontinue DAPT according to level of uncovered strut (≤6%) at 3months OCT follow up after stent implantation. |
|
| The occurrence of the composite of All cause death, spontaneous MI, Target vessel revascularization and stroke. | 12 months after PCI |
| Target vessel revascularization | 12 months after PCI |
| TIMI-defined major bleeding for 12 months | 12 months after PCI |
| Lee SY, Ahn CM, Yoon HJ, Hur SH, Kim JS, Kim BK, Ko YG, Choi D, Jang Y, Hong MK. Early Follow-Up Optical Coherence Tomographic Findings of Significant Drug-Eluting Stent Malapposition. Circ Cardiovasc Interv. 2018 Dec;11(12):e007192. doi: 10.1161/CIRCINTERVENTIONS.118.007192. |
| 29454763 | Derived | Lee SY, Kim JS, Yoon HJ, Hur SH, Lee SG, Kim JW, Hong YJ, Kim KS, Choi SY, Shin DH, Nam CM, Kim BK, Ko YG, Choi D, Jang Y, Hong MK. Early Strut Coverage in Patients Receiving Drug-Eluting Stents and its Implications for Dual Antiplatelet Therapy: A Randomized Trial. JACC Cardiovasc Imaging. 2018 Dec;11(12):1810-1819. doi: 10.1016/j.jcmg.2017.12.014. Epub 2018 Feb 14. |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D062645 | Percutaneous Coronary Intervention |
| ID | Term |
|---|---|
| D057510 | Endovascular Procedures |
| D014656 | Vascular Surgical Procedures |
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019060 | Minimally Invasive Surgical Procedures |
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