Efficacy of a Mouthwash Containing Propolis

Clinical Evidence Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: Phase III, Randomized, Double-blind Comparison With Mouthwash Chlorhexidine Base.

Characterization of green propolis and development of mouthwash containing propolis to control plaque and gingivitis. A Phase I.

Chemical characterization of propolis by HPLC (High-performance liquid chromatography), antimicrobial testing against pathogens and cariogenic. Studies in vitro on anti-inflammatory activity, cytotoxicity tests of green propolis.

Inclusion Criteria:

• age ranging from 18 to 60 years
• minimum of 20 natural teeth
• mean plaque index (PI)of at least 1.5
• an average gingival index (GI), at least less than 1.0.

Exclusion Criteria:

• Individuals with orthodontic appliances or removable dentures,
• Individuals whit tumors of soft tissue or hard mouth, and advanced periodontal disease,
• Indivuduals whit antibiotic therapy 2 weeks prior to study initiation, or with known hypersensitivity propolis are also excluded.