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| ID | Type | Description | Link |
|---|---|---|---|
| M-20100041 |
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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
| Aarhus University Hospital | OTHER |
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Men with Klinefelter syndrome undergo unilateral subcapsular ochiectomy, and the removed testicular tissue is examined for presence of sperm and cryopreserved in small pieces for fertility treatment and scientific purposes. Prior to operation blood samples are frozen in a biobank.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Orchiectomy | Experimental | The patients undergo subcapsular orchiectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Orchiectomy | Procedure | The patients undergo subcapsular orchiectomy with basic surgical instruments. The patients are given local analgesia and sometimes universal anesthesia. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence of testicular sperm | Between 1 and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate after ICSI with retrieved testicular sperm | participants will be followed for the duration of fertility treatment, an expected average of 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Predictive value of FSH and other hormones for the presence of testicular sperm | Between 1 and 6 months |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertility Clinic, Odense University Hospital | Odense | 5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26254174 | Result | Fedder J, Gravholt CH, Kristensen SG, Marcussen N, Engvad B, Milton AM, Andersen CY. Testicular Sperm Sampling by Subcapsular Orchiectomy in Klinefelter Patients: A New Simplified Treatment Approach. Urology. 2015 Oct;86(4):744-50. doi: 10.1016/j.urology.2015.06.044. Epub 2015 Aug 4. |
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| ID | Term |
|---|---|
| D007713 | Klinefelter Syndrome |
| ID | Term |
|---|---|
| D058533 | Sex Chromosome Disorders of Sex Development |
| D012734 | Disorders of Sex Development |
| D014564 | Urogenital Abnormalities |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D009919 | Orchiectomy |
| ID | Term |
|---|---|
| D002369 | Castration |
| D013507 | Endocrine Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D013519 | Urogenital Surgical Procedures |
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| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D025064 | Sex Chromosome Disorders |
| D025063 | Chromosome Disorders |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D030342 | Genetic Diseases, Inborn |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D007006 | Hypogonadism |
| D013521 | Urologic Surgical Procedures, Male |
| D013520 | Urologic Surgical Procedures |