Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(NERD)

Randomized, Double-blind, Active-controlled, Multi-center Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(NERD)

Randomized, double-blind, active-controlled, multi-center phase 2 clinical trial to investigate the safety, tolerability and efficacy of YH1885L in patients with non-erosive reflux disease(NERD)

Inclusion Criteria:

• subjects who signed written informed consent form
• more than 20 yr subject
• subjects who agree the use of medically accepted birth control during trial
• grade N, M by EGD test
• subject who experience 2 day out of 1 week during recent 1 month
• subject who experience 2 day out of 1 week during run-in period

Exclusion Criteria:

• subjects who can write the diary by himself, herself
• pregnant woman, breastfeeding woman
• allgeric or intolerabiliy to revaprazan or esomeprazole
• feeling of heavy stomach, distention
• surgery history in stomach or esophagus
• active medical history of stomach, esophagus area
• other system disorder which can disturb this trial
• Hep B, C virus, HIV carrier or patients
• past history of malignant tumor
• any psychiatric past or current history
• abnormal lab test
• abnormal ecg test
• zollinger-ellison disease
• current or past history of substance, drug abuse
• subject who should regulary takes medication which can disturb this trial