The Study of Breast MRI Screening and Proton Magnetic Resonance Spectroscopy

The Study of Breast MRI Screening and Proton Magnetic Resonance Spectroscopy

To delineate if the chemical composition (lipid and water) in the presumably normal breast of the high risk women is different from those of the low risk group.

The researchers would like to investigate and compare the chemical composition in the normal breast between high risk women and general population.

Inclusion Criteria:

• Women without breast symptoms (without family history of breast cancer; or with at least first-degree relative of breast cancer) with negative mammography and ultrasound result in recent 3 months or contralateral normal breasts from women with newly diagnosed unilateral breast cancer
• 25-75 years old.

Exclusion Criteria:

• renal function impairment
• past history of anaphylactoid reaction to MRI contrast media (Gd-DTPA)
• pregnant or lactating women
• medication of HRT or oral pills in recent 6 months
• past history of surgery of the breast (either side)
• past history of breast cancer
• with breast implant or silicone injection
• past history of cardiac surgery, mechanical valve replacement, aneurismal clip, endotracheal tube or tracheostomy tube, any metallic implants.