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Pseudomonas is a common and virulent respiratory bacteria in patients with Cystic Fibrosis (CF). With time, the infection with Pseudomonas becomes chronic and very difficult to eradicate. The standard treatment of chronic Pseudomonas infection is inhaled Tobramycin which is given every other month.. Inhalation of Tobramycin was proven as an effective treatment that improves the respiratory function and reduces the concentration of bacteria in the sputum. However, inhaled treatment lasts between 15 to 30 minutes twice a day and therefore adherence is a major problem. The effect of switching from inhalation treatment to inhaler treatment on patient's adherence and quality of life has not been studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CF patients with chronic pseudomonas infection |
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| Measure | Description | Time Frame |
|---|---|---|
| Improvement in quality of life | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in exacerbation events | To be measured by: Worsening of CF symptoms such as coughing, sputum, deterioration in FEV1, all of which require hospitalization | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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CF patients with chronic pseudomonas infection
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ori Sarouk, MD | Contact | 97235302884 | ifat.sarouk@sheba.health.gov.il |
| Name | Affiliation | Role |
|---|---|---|
| Ori Efrati, MD | Safra Children's hospital, National CF Center | Principal Investigator |
| Ifat Sarouk, MD | Safra Children's Hospital, National CF center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Safra Children's Hospital, Sheba Medical Center | Ramat Gan | Israel |
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
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