Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of the study is to evaluate the autonomic failure in Parkinson's disease by clinical, electrophysiological and neuropathological examination.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biopsies of peripheral autonomic nervous system | Other | |||
| Autonomic dysfunction questionnaires | Other |
| ||
| Electrophysiological tests | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate association between clinical autonomic failure and neuropathological autonomic failure on biopsies. | the main objective is to look after associations between :
| 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate association between autonomic failure and severity factors in Parkinson's disease | Autonomic failure will be assessed through questionaries on symptoms and through functional tests. Severity factors in parkinson disease will refer to various parameters like patient age. | 3 months |
| Evaluate consequences of autonomic failure on quality of life and sleep quality |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes Universitary Hospital | Nantes | Loire Atlantique | 44093 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38156524 | Derived | Sadoc M, Clairembault T, Coron E, Berthomier C, Le Dily S, Vavasseur F, Pavageau A, St Louis EK, Pereon Y, Neunlist M, Derkinderen P, Leclair-Visonneau L. Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson's disease. Sleep. 2024 Mar 11;47(3):zsad310. doi: 10.1093/sleep/zsad310. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D054970 | Pure Autonomic Failure |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
quality of life and of sleep will be assessed through functional tests and through questionaries. |
| 3 months |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D054969 | Primary Dysautonomias |
| D001342 | Autonomic Nervous System Diseases |