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| ID | Type | Description | Link |
|---|---|---|---|
| 2010-A00172-37 | Other Identifier | ANSM |
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Microcirculatory disturbances following cardiac surgery with cardiopulmonary bypass (CPB) have been thought to be at the origin of organ dysfunction. Though, few studies correlated microvascular alterations with outcome. Investigators aimed at firstly describing microcirculation with near infra red spectroscopy (NIRS) and secondly correlating NIRS parameters with intensive care length of stay and organ dysfunction.
40 patients at high risk of post operative systemic inflammatory response syndrome after an elective cardiac surgery with CPB were included in this prospective observational study. Patients were studied during the first 48 postoperative hours. Microcirculation of the thenar eminence was analyzed by NIRS technology, through the StO2 and the resaturation slope after an ischemic challenge. Organ dysfunction was assessed with the SOFA score.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| microcirculatory reactivity | Patients were studied during the first 48 postoperative hours. Microcirculation of the thenar eminence was analyzed by NIRS technology, through the StO2 and the resaturation slope after an ischemic challenge. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| microcirculatory reactivity | Other | Microcirculation of the thenar eminence was analyzed by NIRS technology, through the StO2 and the resaturation slope after an ischemic challenge. |
| Measure | Description | Time Frame |
|---|---|---|
| microcirculatory reactivity | Tissue oxygen saturation (StO2) measure by a tissue spectrometer with a 25 mm probe spacing placed on the thenar eminence | 10 minutes before anesthésia induction |
| Measure | Description | Time Frame |
|---|---|---|
| microcirculatory reactivity | Tissue oxygen saturation (StO2) measure by a tissue spectrometer with a 25 mm probe spacing placed on the thenar eminence | during CPB (30 minutes after the start), and 2, 6, 12, 24 and 48 hours after the end of the CPB |
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Inclusion Criteria:
Exclusion Criteria:
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patients at high risk of post operative systemic inflammatory response syndrome after an elective cardiac surgery with CPB
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| Name | Affiliation | Role |
|---|---|---|
| Jerome MOREL, Md | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Saint-Etienne | Saint-Etienne | 42055 | France |
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