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DXA scanners are routinely used to assess bone mineral density (BMD) and fracture risk in osteoporosis patients. They provide detailed bone imaging in a low radiation setting. Hologic manufactures scanners that are able to perform high definition instant vertebral fracture assessment (HD-IVA) used to screen at-risk patients for asymptomatic spine fractures instantly and reliably at the same time they are having their yearly BMD. We wish to investigate whether this same proven technology (HD-IVA scan mode) used on femurs (the scan mode is now called SE Femur scans) can be used to screen for atypical fractures of the femur in patients at risk for these debilitating fractures. In this proof of concept study, we propose to examine whether DXA scanners can provide a sensitive low radiation screening method to identify incomplete AFFs in patients with known incomplete AFFs and in patients at risk.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Screening population | Healthy post-menopausal women attending bone mineral density screening clinic with leg/hip/groin pain/discomfort/weakness an has been on anti-resorptive therapy for at least 5 years. |
| |
| Comparator Group | Control group from Toronto CaMOS cohort willing to participate. |
| |
| AFF group | participants in the AFF Cohort study at UHN |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DXA Se femur scans (previously called IVA femur) | Device | Single Energy Beam (previously called inter-vertebral assessment) by Dual energy x-ray absorptiometry of affected femur |
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| Measure | Description | Time Frame |
|---|---|---|
| HD-IVA visualization of incomplete femur fractures | Hologic DXA scanner using the high-definition IVA (HD-IVA) mode on femur bones will be able to visualize incomplete femur fractures at least 90% of the time in patients with known incomplete AFF. | 1 day (one time point ) |
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Inclusion Criteria:
Known AFF group
Comparison Group
Exclusion Criteria:
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Osteoporosis/Bone Mineral Density Lab out-patients
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| Name | Affiliation | Role |
|---|---|---|
| Angela M Cheung, MD, PhD, CCD | University Health Network, Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Health Network | Toronto | Ontario | M5G 2C4 | Canada |
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