Pharmacokinetics of Resveratrol Comprising Products

Randomized Three-way Cross-over Comparative Pharmacokinetic Study of Resveratrol Comprising Products in Fasting Healthy Subjects

This study was designed to assess the pharmacokinetics of 2 doses of Red Grape Cells (RGC) containing resveratrol compared with a reference. RGC will be administered as single oral dose to fasting healthy volunteers. Plasma concentration of free resveratrol and total conjugates will be analyzed.

Inclusion Criteria:

• Ages 18-55 years;
• BMI >/= 19 and </= 30
• non smoking
• without history or evidence of significant cardiovascular, hepatic, renal, respiratory, gastrointestinal disease
• normal physical and laboratory examinations

Exclusion Criteria:

• History or evidence of alcohol or drug abuse
• subjects receiving chronic medication
• unusual dietary habits or a recent change in body weight
• acute medical situation 48 hours prior to initiation of the study
• poor venous access
• Subjects participated in a trial or donated blood within 4 weeks before initiation of the study