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This study was designed to assess the pharmacokinetics of 2 doses of Red Grape Cells (RGC) containing resveratrol compared with a reference. RGC will be administered as single oral dose to fasting healthy volunteers. Plasma concentration of free resveratrol and total conjugates will be analyzed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RGC1 | Experimental | RGC containing the equivalent of 50 mg resveratrol |
|
| Resveratrol | Active Comparator | The equivalent of 150 mg resveratrol |
|
| RGC2 | Experimental | RGC containing the equivalent of 150 mg resveratrol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RGC | Dietary Supplement |
| ||
| RGC |
| Measure | Description | Time Frame |
|---|---|---|
| Individual plasma concentrations of free and conjugated resveratrol | Pharmacokinetic data such as the peak plasma concentration (Cmax), time to peak (Tmax) ans area under the concentration-time curves (AUCt) will be reported. | 24 hours |
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Inclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BioStudies Center | Beersheba | 84101 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24827888 | Derived | Azachi M, Yatuv R, Katz A, Hagay Y, Danon A. A novel red grape cells complex: health effects and bioavailability of natural resveratrol. Int J Food Sci Nutr. 2014 Nov;65(7):848-55. doi: 10.3109/09637486.2014.917152. Epub 2014 May 15. |
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| ID | Term |
|---|---|
| D000077185 | Resveratrol |
| ID | Term |
|---|---|
| D000081225 | Stilbestrols |
| D013267 | Stilbenes |
| D001597 | Benzylidene Compounds |
| D001555 | Benzene Derivatives |
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|
| Resveratrol | Dietary Supplement | The equivalent of 150 mg resveratrol |
|
|
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D059808 | Polyphenols |
| D010636 | Phenols |