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Traditional Chinese Medicine (TCM) could be used to treat Recurrent urinary tract infection (RUTI).
Antibiotics and TCM are used to treat RUTI to evaluate treatment efficiencies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LVX-AMX | Active Comparator | subject is treated with LAV-AMX, then followed by placebo. |
|
| TCM treatment | Active Comparator | subject is treated with TCM |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LVX-AMX | Drug | Subjects were treated with Levofloxacin, 200mg bid, Amoxicillin, 500mg tid for 1 week, followed by 3 week of placebo. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Recovery of recurrent urinary tract infection | Patients are checked at 4 weeks at the end of the treatment to confirm recovery of RUTI. | 4 weeks after study drug start |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary albumin | Urinary albumin is checked in patient urine. | 4 weeks after drug start |
| WBC conversion | Check the WBC count in patient urine. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shiwei Liu, Dr | Contact | 86-10-84739029 | liushiwei1977@yeah.net |
| Name | Affiliation | Role |
|---|---|---|
| Zeliang Chen, Dr | Insititute of Disease Control and Prevention | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wangjing Hospital | Recruiting | Beijing | Beijing Municipality | 100020 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28741061 | Derived | Liu SW, Guo J, Wu WK, Chen ZL, Zhang N. Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial. Chin J Integr Med. 2019 Jan;25(1):16-22. doi: 10.1007/s11655-017-2960-4. Epub 2017 Jul 25. |
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| ID | Term |
|---|---|
| D014552 | Urinary Tract Infections |
| ID | Term |
|---|---|
| D007239 | Infections |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D064704 | Levofloxacin |
| C494814 | BID protein, human |
| D000658 | Amoxicillin |
| ID | Term |
|---|---|
| D015242 | Ofloxacin |
| D024841 | Fluoroquinolones |
| D042462 | 4-Quinolones |
| D015363 | Quinolones |
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| TCM | Drug | Subject is treated with TCM for 4 weeks. |
|
|
| LVX-AMX | Drug | treatment with placebo from 2 to 4 weeks. |
|
|
| 4 weeks after drug start |
| Urination frequency | Checked for urination frequency at 4 weeks after drug start. | 4 weeks after drug start |
| Recurrence | Patients are checked for recurrence rate at 6 months after drug start by telephone interview. | 6 months after drug start |
| urgency | Check urgency 4 weeks after drug start | 4 weeks after drug start |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D011804 |
| Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D000667 | Ampicillin |
| D010400 | Penicillin G |
| D010406 | Penicillins |
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013457 | Sulfur Compounds |