The purpose of this study is

1. to estimate the incidence of seizure in the general population and stratified by epilepsy status
2. To estimate the relative risk of seizure associated with use of proton pump inhibitors and histamine 2 receptor antagonist and stratified by epilepsy status

A cohort study with a nested case control analysis on the association between acid-suppressing drugs and seizures using THIN database in the UK

Inclusion Criteria:

• Primary care physician for at least 2 years.
• Computerized prescription history of at least 1 year.
• Patients will have to be free of acid-suppressing drugs (PPI or H2RA) for at least one year.
• No diagnosis of cancer.
• No alcohol abuse or alcohol-related disease- No drug abuse.

Exclusion Criteria:

• Patients with at least 1 prescription of PPI or H2RA in the year prior to start date.
• Cancer before start date.
• Alcohol abuse or alcohol-related disease before start date.
• Drug abuse before start date.

All individuals aged 20-84 years from 1 January 2005 to 31 December 2011, who have been enrolled with their primary care physician for at least 2 years and have a computerized prescription history of at least 1 year. Patients will have to be free of acid-suppressing drugs (PPI or H2RA) for at least one year, and never have a diagnosis of cancer, alcohol abuse or alcohol-related disease, or drug abuse.