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| Name | Class |
|---|---|
| University Hospitals of Derby and Burton NHS Foundation Trust | OTHER |
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Curative treatment for oesophageal cancer involves undertaking chemotherapy followed by an operation to remove the tumour. Chemotherapy has several effects upon the body, including effects upon the systems that control the creation and breakdown of muscle. We aim to review these effects by recording changes in the amount of exercise patients are able to undertake after chemotherapy and reviewing changes in muscle mass.
We aim to review the effects of chemotherapy on skeletal muscle mass and cardio-respiratory performance in patients with oesophageal adenocarcinoma. All patients will be assessed by a Consultant Anaesthetist and a medical member of the Research team before commencing chemotherapy and after finishing their course. These assessments include a nutritional assessment, performance status assessments, blood assays, dual energy X-ray absorptiometry (DEXA) scans, cardio-pulmonary exercise (CPEX) testing and a muscle biopsy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oesophageal adenocarcinoma | DEXA scan cardio-pulmonary exercise testing (CPEX) muscle biopsy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DEXA scan | Radiation | all patients will undertake a full body DEXA scan before and after chemotherapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| muscle mass | variations in muscle mass during neoadjuvant chemotherapy | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| nutritional status | assess nutritional status post chemotherapy via serum protein levels. | 3 months |
| all cause mortality | Evidence of mortality and relate this to aerobic ability. |
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Inclusion Criteria:
Exclusion Criteria:
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healthy volunteers oesophageal cancer patients
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| Name | Affiliation | Role |
|---|---|---|
| John Williams, MBChB, FFPMRCA, PhD | Graduate Entry Medical School, University of Nottingham | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Graduate Entry Medical School, University of Nottingham | Derby | Derbyshire | DE33 2NE | United Kingdom |
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| ID | Term |
|---|---|
| C562730 | Adenocarcinoma Of Esophagus |
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D015502 | Absorptiometry, Photon |
| ID | Term |
|---|---|
| D011859 | Radiography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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blood tests for serum albumin and total protien levels.
| Muscle biopsy | Procedure | All patients will have a muscle biopsy before and after chemotherapy |
|
| cardio-pulmonary exercise testing (CPEX) | Other | patients will undertake exercise in the form of an exercise bike whilst having their cardiac and ventilatory performance analysed. This will take place before and after neoadjuvant chemotherapy |
|
| 3 months |
| mitochondrial function performance status | review changes in mitochondrial function after neoadjuvant chemotherapy | 3 months |
| cardiorespiratory performance (peak VO2) | review changes in cardiorespiratory performance (peak VO2) after neoadjuvant chemotherapy | 3 months |
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D003720 |
| Densitometry |
| D010783 | Photometry |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |