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| ID | Type | Description | Link |
|---|---|---|---|
| 1K23NS072283-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
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Disruption of sleep and alertness is one of the most disabling non-motor symptoms of Parkinson's disease (PD). Mechanisms leading to impaired sleep and alertness in PD are not well understood, and treatment options remain limited. The proposed research will examine markers of the circadian system, sleepiness and sleep quality in PD patients and healthy controls. Further, the project will examine effects of bright light exposure on circadin function, sleep and alertness in PD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | ||
| PD patients without sleep problems | No Intervention | ||
| PD patients with sleep problems | Active Comparator | light exposure |
|
| PD patients with sleep problem | Placebo Comparator | light exposure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Light exposure | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| circadian rhythm of melatonin | June 2012- May 2017 | |
| Sleep Efficiency | June 2012- May 2017 | |
| Daytime Somnolence | June 2012- May 2017 |
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Inclusion Criteria:
Control participants will be matched for gender and age with PD participants.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Aleksandar Videnovic, MD | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D006970 | Disorders of Excessive Somnolence |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D001523 | Mental Disorders |