Pharmacokinetics Of CP-690,550 In Patients With Impaired Renal Function

Phase 1, Open-Label Study To Evaluate Single Dose Pharmacokinetics, Safety And Tolerability Of CP-690,550 In Patients With Impaired Renal Function

A study to evaluate the pharmacokinetics of CP-690,550 in subjects with mild, moderate or severe renal impairment, who do not require hemodialysis, compared to healthy controls.

Inclusion Criteria:

• Subjects with normal renal function: Subjects must be healthy with estimated creatinine clearance >80 mL/min
• Subjects with renal impairment: Subjects should be in good general health commensurate with the population with chronic kidney disease

Exclusion Criteria:

• Kidney transplant patients
• Subjects with any condition possibly affecting drug absorption
• Subjects with malignancies with the exception of adequately treated basal cell carcinoma of the skin