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The purpose of this study is to compare endoscopic radiofrequency ablation with photodynamic therapy for inoperable cholangiocarcinoma
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Self expanding metallic stent （SEMS ）placement only | Active Comparator | Endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) would be performed to confirm the position and length of the biliary malignant. A self expanding metallic stent (SEMS) would be placed to bypass the site of narrowing |
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| Endoscopic radiofrequency ablation plus SEMS | Experimental | Endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) would be performed to confirm the position and length of the biliary malignant. The radiofrequency ablation (RFA) catheter (EMcision, London, United Kingdom) would be placed under fluoroscopic guidance across the biliary stricture. Radiofrequency energy will be delivered to the malignant site. After that,A self expanding metallic stent (SEMS) would be placed to bypass the site of narrowing |
|
| Photodynamic therapy plus SEMS | Experimental | Photofrin is injected 3 days prior to laser activation of the agent.Endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) will be carried out to determine the length and positon of the biliary malignant. Delivery Fiber used along with the laser system to activate the photosensitizing agent and induce tumor tissue necrosis. A self expanding metallic stent (SEMS) will be placed the site of biliary narrowing |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Self expanding metallic stent (SEMS) | Procedure | Self expanding metallic stent |
|
| Measure | Description | Time Frame |
|---|---|---|
| stent patency | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| overall survival rate | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Huihong Liang, MD | Contact | +86-20-34153043 | beanth@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Second Hospital of Guangzhou Medical College | Not yet recruiting | Guangzhou | Guangdong | 510260 | China |
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| Endoscopic radiofrequency ablation (ERFA) | Procedure | Endoscopic radiofrequency ablation |
|
| Photodynamic therapy (PDT) | Procedure | Photodynamic therapy |
|
| The second hospital of Guangzhou Medical college | Recruiting | Guangzhou | Guangdong | 510260 | China |
|
| ID | Term |
|---|---|
| D018281 | Cholangiocarcinoma |
| D009369 | Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D001649 | Bile Duct Diseases |
| D001660 | Biliary Tract Diseases |
| D003251 | Constriction, Pathologic |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| ID | Term |
|---|---|
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D010778 | Photochemotherapy |
| ID | Term |
|---|---|
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D004358 | Drug Therapy |
| D010789 | Phototherapy |
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