Comparison of Endoscopic Radiofrequency Ablation Versus Photodynamic Therapy for Inoperable Cholangiocarcinoma

A Randomized Controlled Trial Comparing Endoscopic Biliary Radiofrequency Ablation With Photodynamic Therapy for Inoperable Cholangiocarcinoma

The purpose of this study is to compare endoscopic radiofrequency ablation with photodynamic therapy for inoperable cholangiocarcinoma

Inclusion Criteria:

• Age ≥ 18 years old
• Pathologically or radiologically confirmed biliary malignant
• Inoperability by staging

Exclusion Criteria:

• Cholangiocarcinoma with widespread metastasis
• Coagulopathy (INR > 2.0 or prothrombin time > 100 sec or platelet count < 50,000)
• Prior SEMS placement
• Pregnancy
• Eastern Cooperative Oncology Group (ECOG) performance status ≥ 3 )
• Life expectancy < 3months