Exposure Study Comparing 3 Routes of Methotrexate (MTX) Administration

Exposure, Safety and Local Tolerance Study Comparing 3 Routes of Methotrexate (MTX) Administration: Vibex-MTX Device, Subcutaneous (SC)and Intramuscular (IM) in Adult Subjects With Rheumatoid Arthritis

Pharmacokinetics (PK) study

To compare the pharmacokinetic (PK) profiles of methotrexate (MTX) following a subcutaneous (SC) injection of MTX using the Vibex device to that obtained after an SC injection of MTX without using the device and to that obtained after an intramuscular (IM) injection of MTX in adult subjects with rheumatoid arthritis (RA).

Inclusion Criteria:

• Male or female >18 years of age with diagnosed Rheumatoid Arthritis(RA).

Exclusion Criteria:

• Chronic or acute renal disease
• Any other clinically significant disease or disorder which, in the opinion of the investigator, might put the subject at risk