Comparison of Pantoprazole and Ranitidine in Dyspepsia

Intravenous Pantoprazole vs Ranitidine in Dyspepsia in Emergency Department: A Randomized Controlled Trial.

The H0 hypothesis of the study is there is no difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department.

The H1 hypothesis is there is difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department.

Dyspepsia is one of the common complaints in emergency department. Proton pomp inhibitors, H2 receptor blockers and anti-acids are common drugs for treating dyspepsia in emergency department. However there is no study in the emergency department comparing the effectiveness of these drugs. So the investigators planned this study which drug is effective in these patients in order to provide a cost-effective treatment in dyspeptic patients.

Inclusion Criteria:

• Epigastric pain
• Older than 18 years old

Exclusion Criteria:

• Diagnosed as cholecystitis, pancreatitis, myocardial infarction, etc.. at the end of the emergency deparment evaluation period.
• Pregnancy
• Patients with unstable vital signs
• Patients used anti-acid, H2 receptor blockers and proton pomp inhibitors in the last one hour.
• Allergy to H2 receptor blockers and proton pomp inhibitors.
• Patients denied to give inform consent and who are illiterate