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To examine the benefits of using a video-game, Dance, Dance, Revolution, as an exercise modality to improve gait and balance in individuals with Huntington's disease.
The primary purpose of this study was to determine the effectiveness of a therapist-guided Video-game Biofeedback Modulated Exercise (ViBE) program administered via Dance Dance Revolution to improve dynamic balance, gait and mobility in individuals with Huntington's Disease. Secondary aims were to explore whether the ViBE intervention would improve quality of life, fall risk, and neuropsychological functions. The investigators hypothesized that the video-game program would lead to greater improvements in walking, dynamic balance, quality of life, fall risk, and neuropsychological function than a control handheld video game program. Since motivation is essential to the long-term maintenance of an exercise program the investigators were also interested in finding out how successful people with Huntington's Disease were at playing Dance Dance Revolution, what their perceptions were of playing the game, and whether they thought that it was beneficial
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| video game exercise | Experimental | Video game exercise using Dance Dance Revolution |
|
| control | Other | hand-held video game control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Video game exercise using Dance Dance Revolution | Other | use of the video-game, Dance, Dance Revolution as an exercise to improve gait and balance |
|
| Measure | Description | Time Frame |
|---|---|---|
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward velocity. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward stride length. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward swing percent. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward double support percent. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward heel to heel base of support. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards velocity. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards stride length. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards swing percent. |
| Measure | Description | Time Frame |
|---|---|---|
| Tinetti Mobility Test | Observation of gait and balance with quantifiable 16-item assessment with an ordinal scale of 0-2 for up to a total score of 32, with higher scores indicating better performance. It is reliable and predicts falls among those with Parkinson's disease and Huntington's disease. | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Deb Kegelmeyer, DPT, MS | Ohio State University | Principal Investigator |
| Anne Kloos, PT, PhD | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Ohio State University Atwell Hall | Columbus | Ohio | 43210 | United States |
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| ID | Title | Description |
|---|---|---|
| FG000 | Dance Dance Revolution Exercise, Then Hand Held Video Game (Control) | Participants first completed the video game exercise using Dance Dance Revolution: use of the video-game, Dance, Dance Revolution as an exercise to improve gait and balance. Then participated in a hand held video game as the control activity. |
| FG001 | Hand Held Video Game (Control), Then Dance Dance Revolution Exercise | Individuals first participated in the control group: a hand-held video game. Then completed the video game exercise using Dance Dance Revolution: use of the video-game, Dance, Dance Revolution as an exercise to improve gait and balance. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allocated |
| |||||||||||||
| Crossed Over |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Dance Dance Revolution Exercise, Then Hand Held Video Game (Control) | Participants first completed the video game exercise using Dance Dance Revolution: use of the video-game, Dance, Dance Revolution as an exercise to improve gait and balance. Then participated in a hand held video game as the control activity. |
| BG001 |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward velocity. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | meters per second | 6 weeks |
|
Course of the time from when the participant was enrolled in the study (8-12 weeks)
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Dance Dance Revolution Exercise | All participants who were initially enrolled into the group with the video game exercise using Dance Dance Revolution either in the first 6 weeks of the study or the second 6 weeks. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Anne Kloos | The Ohio State University | 614-688-5942 | kloos.4@osu.edu |
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| ID | Term |
|---|---|
| D006816 | Huntington Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Participants completed one arm of the study and then crossed over into the other arm of the study
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|
| hand-held video game | Other | hand-held video games |
|
| 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards double support percent. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards heel to heel base of support. | 6 weeks |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: obstacle velocity. | 6 weeks |
| Four Square Step Test |
Examines ability to step over an object in multiple directions and is timed. Participants are instructed to step over a cane into each square in a specific order. Faster times indicate better balance. It has been shown to predict falls in the elderly. |
| 6 weeks |
| Activities-Specific Balance Confidence Scale | Individuals rate their balance confidence from 1-100 on 16 tasks and total score is the mean; higher scores indicate greater confidence and lower fall risk. The Activities-Specific Balance Confidence Scale is reliable and valid in elderly and neurological populations. | 6 weeks |
| World Health Organization Quality of Life | This questionnaire is a measure of quality of life addressing 4 domains including physical, psychological, social, and environment health. Responses on 26 items are on a five-point scale (from 1 = very dissatisfied to 5 = very satisfied) and each item is added to achieve a total score for each domain. The mean score for each domain is calculated then multiplied by 4 to get the domain score which are then transformed to a scaled score of 0-100 comparable to the original WHOQOL-100 therefore a total score between 0-400 with high scores indicating better quality of life. The WHOQOLBref has good reliability and validity. | post intervention and post hand-held game, each lasts 6 weeks |
| NOT COMPLETED |
|
| Hand Held Video Game (Control), Then Dance Dance Revolution Exercise |
Individuals first participated in the control group: a hand-held video game. Then completed the video game exercise using Dance Dance Revolution: use of the video-game, Dance, Dance Revolution as an exercise to improve gait and balance. |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
All participants that completed the hand-held video game control group for the first 6 weeks or the second 6 weeks of the study. |
|
|
| Secondary | Tinetti Mobility Test | Observation of gait and balance with quantifiable 16-item assessment with an ordinal scale of 0-2 for up to a total score of 32, with higher scores indicating better performance. It is reliable and predicts falls among those with Parkinson's disease and Huntington's disease. | Posted | Mean | Standard Deviation | score on a scale | 6 weeks |
|
|
|
| Secondary | Four Square Step Test | Examines ability to step over an object in multiple directions and is timed. Participants are instructed to step over a cane into each square in a specific order. Faster times indicate better balance. It has been shown to predict falls in the elderly. | Loss of one participant in Four-Square Step Test due to incomplete data | Posted | Mean | Standard Deviation | seconds | 6 weeks |
|
|
|
| Secondary | Activities-Specific Balance Confidence Scale | Individuals rate their balance confidence from 1-100 on 16 tasks and total score is the mean; higher scores indicate greater confidence and lower fall risk. The Activities-Specific Balance Confidence Scale is reliable and valid in elderly and neurological populations. | Posted | Mean | Standard Deviation | score on a scale | 6 weeks |
|
|
|
| Secondary | World Health Organization Quality of Life | This questionnaire is a measure of quality of life addressing 4 domains including physical, psychological, social, and environment health. Responses on 26 items are on a five-point scale (from 1 = very dissatisfied to 5 = very satisfied) and each item is added to achieve a total score for each domain. The mean score for each domain is calculated then multiplied by 4 to get the domain score which are then transformed to a scaled score of 0-100 comparable to the original WHOQOL-100 therefore a total score between 0-400 with high scores indicating better quality of life. The WHOQOLBref has good reliability and validity. | Loss of one participant for the WHOQOL-Bref due to incomplete data | Posted | Mean | Standard Deviation | score on a scale | post intervention and post hand-held game, each lasts 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward stride length. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | cm | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward swing percent. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | percentage of gait cycle spent in swing | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward double support percent. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | percent of gait cycle in double support | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward heel to heel base of support. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | cm | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards velocity. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | meters per second | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards stride length. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | cm | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards swing percent. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | percentage of gait cycle spent in swing | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards double support percent. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | percent of gait cycle in double support | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards heel to heel base of support. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | cm | 6 weeks |
|
|
|
| Primary | Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: obstacle velocity. | GAITRite outcome data was eliminated for one participant who consistently exhibited an abnormal gait during testing sessions on the walkway that did not reflect his usual walking pattern. One participant could not walk backward. Thus, 17 participants were included in the GAITRite analysis (n = 16 for backward condition). | Posted | Mean | Standard Deviation | meters per second | 6 weeks |
|
|
|
| 0 |
| 24 |
| 0 |
| 24 |
| 0 |
| 24 |
| EG001 | Hand Held Video Game (Control) | All participants that who were initially enrolled into the control group with the hand-held video game control for the first 6 weeks or the second 6 weeks of the study. | 0 | 18 | 0 | 18 | 0 | 18 |
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| D003704 | Dementia |
| D002819 | Chorea |
| D020820 | Dyskinesias |
| D009069 | Movement Disorders |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |