Role of Prohepcidin in Uremic Patients

The Relationship of Prohepcidin Levels With Anemia and Inflammatory Markers in Non-diabetic Uremic Patients: A Controlled Study

The investigators aimed to study the effect of prohepcidin levels on hematologic parameters and inflammatory markers in non-diabetic uremic patients. The investigators selected three groups of patients: Hemodialysis group, peritoneal dialysis group and the group with stage 4 chronic kidney disease. A control group was formed from healthy volunteers also. Each group has been planned to be formed of about 25 patients. Diabetic patients were excluded. Prohepcidin, hsCRP, IL-6, fibrinogen have been planned to be studied besides other routine biochemical analysis including hematological ones.

Inclusion Criteria:

• hemodialysis and peritoneal dialysis patients who had been on dialysis therapy for more than 3 months,
• age between 18-80 years,
• patients with creatinine clearance between 15-30 ml/min.

Exclusion Criteria:

• age less than 18 or more than 80,
• diabetic patients,
• current active infectious or inflammatory disease.