Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells

Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells

The recent developments of research on iPS (induced pluripotent stem) cells lead to the establishment of mature cell lines such as cardiomyocytes or valvular interstitial cells with genetic and cellular characteristics of the donors. These cells represent a biological material more readily available to identify the pathophysiological mechanisms involved in the diseases of BrS or ERS patients, which will lead to the identification of genetic markers.

Inclusion criteria:

• Patient with a family history of inherited arrhythmia or valvulopathy
• Age : 22-60 yo.
• patient no confine to bed
• Male or female
• Written consent
• Patient affiliated to the French social security

Exclusion criteria:

• Pregnant woman
• Patient under 22 yo or adults under guardianship
• Indication against local anesthesia
• Anticoagulant treatment
• Absence or positivity of HIV, HBV, HCV serology