Efficacy and Safety of Prunus Mume Extract on Improvement of Constipation

The investigators performed a 8-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of Prunus Mume Extract on Improvement of Constipation. The investigators measured Improvement of Constipation parameters , including Colonic Transit Time, number of bowel movement, defecation time, stool type, color and stool amounts per defecation, and monitored their blood pressure.

Inclusion Criteria:

• Males and females 19-40 years old
• Subject who have functional constipation by ROME IIII criteria
• Subject who have over 36 hour colonic transit time
• Able to give informed consent

Exclusion Criteria:

• Subject who have Irritable bowel syndrome by ROME IIII criteria
• Allergic or hypersensitive to any of the ingredients in the test products
• History of reaction to any of the test products or of gastrointestinal diseases such as Crohn's disease or gastrointestinal surgery
• History of alcohol or substance abuse
• Participation in any other clinical trials within past 2 months
• Laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the study
• Pregnant or lactating women etc.