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The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oral quercetin capsules | Active Comparator | Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks |
|
| oral placebo capsules | Placebo Comparator | Patients in the placebo group received two placebo capsules containing lactose . |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oral quercetin capsules | Drug | 10 cases in case group and 10 cases in control group. Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks. Patients in the placebo group received two placebo capsules containing lactose .Patients were examined every other day for evaluation of initiation and severity of oral mucositis. |
| Measure | Description | Time Frame |
|---|---|---|
| lower grade of mucositis | grade of mucositis due to WHO criteria | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| duration of mucositis | duration of mucositis due to Who criteria | 3 weeks of study tiem span and after trial |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pegah Mosannen Mozafari, assistant professor | Mashhad University of Medical Sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oral Medicine Department of Mashhad dental School | Mashhad | Razavi Khorasan Province | 91735-498 | Iran |
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| ID | Term |
|---|---|
| D052016 | Mucositis |
| D019337 | Hematologic Neoplasms |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D009059 | Mouth Diseases |
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| ID | Term |
|---|---|
| D011794 | Quercetin |
| ID | Term |
|---|---|
| D044948 | Flavonols |
| D005419 | Flavonoids |
| D002867 | Chromones |
| D001578 | Benzopyrans |
| D011714 |
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|
| Placebo | Drug |
|
| D009057 |
| Stomatognathic Diseases |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |