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The purpose of this study is to assess exercise performance in 20 healthy children 10-19 years of age with a body mass index greater than 85th percentile and to evaluate the effect of dietary and exercise intervention over 12 weeks.
Our hypothesis is that the vascular health in these children will improve at the end of intervention. The results of this study will help us in our long-term objective of improving vascular health of children with congenital/acquired heart disease, a group particularly at risk for premature atherosclerosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diet and Exercise Intervention | Experimental | Tests will include EndoPAT analysis to assess endothelial function, applanation tonometry to assess arterial stiffness, carotid artery imaging to assess the wall thickness of the carotid arteries, exercise testing to assess the physical exercise capacity of these children and blood work to evaluate the lipid profile and inflammation status (CRP). The Home Exercise Program will be 3 days a week for 12 weeks and participants will connect with the trainer to perform 45-60 minutes of a combination of strength training and aerobic activity via Skype. The Dietary Approaches to Stop Hypertension(DASH) eating pattern will be prescribed to all participants in the treatment group and specific strategies to achieve goals will be discussed weekly by the participant over the phone. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diet and Exercise Intervention | Other | Remote Dietary and Exercise Intervention Program |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vascular Health | Tests will include: EndoPAT analysis to assess endothelial function, applanation tonometry to assess arterial stiffness, carotid artery imaging to assess the wall thickness of the carotid arteries, exercise testing to assess the physical exercise capacity of these children and blood work to evaluate the lipid profile and inflammation status (CRP). The participant will be asked to come in after an overnight fast. They will receive a snack bag before the exercise test. | Beginning of 12th week and end of 12th week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Seda Tierney, MD | Lucile Packard Children's Hospital - Pediatric Cardiology | Principal Investigator |
| Chau N Vu, BS | Lucile Packard Children's Hospital - Pediatric Cardiology | Study Director |
| Katie Jo Buccola | Lucile Packard Children's Hospital - Pediatric Cardiology | Study Chair |
| Jeffrey Kazmucha | Lucile Packard Children's Hospital - Pediatric Cardiology | Study Chair |
| Laurie Steinberg | Stanford Prevention Research Center | Study Chair |
| Olga Ogareva | Lucile Packard Children's Hospital - Pediatric Cardiology | Study Chair |
| Inger Olson, MD | Lucile Packard Children's Hospital - Pediatric Cardiology | Study Chair |
| Chinyelu Nwobu, MD | Lucile Packard Children's Hospital - Pediatric Cardiology | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lucile Packard Children's Hospital at Stanford | Palo Alto | California | 94306 | United States |
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| ID | Term |
|---|---|
| D010349 | Patient Compliance |
| ID | Term |
|---|---|
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D004032 | Diet |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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