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| ID | Type | Description | Link |
|---|---|---|---|
| EUC-019 | Other Grant/Funding Number | European University Cyprus |
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| Name | Class |
|---|---|
| Aristotle University Of Thessaloniki | OTHER |
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The purpose of the present investigation is to compare the responses and adaptations of young and elderly individuals to repeated eccentric exercise in regards to muscle function and redox homeostasis in a side-by-side comparison.
Despite the progress of analytic techniques and the refinement of study designs, striking disagreement exists among studies regarding the influence of exercise on muscle function and redox homeostasis in the elderly. A specific exercise protocol will be applied (the repeated eccentric model) to produce long-lasting and extensive changes in redox biomarkers and to examine more easily the potential effects of aging. Ten young men and ten elderly men will underwent an isokinetic eccentric exercise session, which will be repeated after three weeks. Muscle function indices and redox biomarkers will be assessed in urine, plasma or erythrocytes pre exercise, immediately post exercise, 2 and 4 days post exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Young group | Experimental | Participants will underwent two isokinetic eccentric exercise sessions |
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| Elderly group | Experimental | Participants will underwent two isokinetic eccentric exercise sessions |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other | Participants will perform two isokinetic eccentric exercise bouts |
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| Measure | Description | Time Frame |
|---|---|---|
| Muscle torque (torque) | Change in muscle torque from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise | |
| Range of motion, ROM (degrees) | Change in ROM from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise | |
| Delayed onset muscle soreness, DOMS (scale 1-10) | Change in DOMS from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise | |
| Creatine kinase, CK (activity IU) | Change in CK from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| Measure | Description | Time Frame |
|---|---|---|
| F2-isoprostanes (pg/mg creatinine) | Change in F2-isoprostanes from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise | |
| Protein carbonyls (nmol/mg protein) | Change in F2-isoprostanes from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michalis G Nikolaidis, PhD | Aristotle University Of Thessaloniki | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| European University Cyprus | Nicosia | 1516 | Cyprus |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20951733 | Background | Nikolaidis MG, Kyparos A, Vrabas IS. F(2)-isoprostane formation, measurement and interpretation: the role of exercise. Prog Lipid Res. 2011 Jan;50(1):89-103. doi: 10.1016/j.plipres.2010.10.002. Epub 2010 Oct 15. | |
| 19712664 | Background | Nikolaidis MG, Jamurtas AZ. Blood as a reactive species generator and redox status regulator during exercise. Arch Biochem Biophys. 2009 Oct 15;490(2):77-84. doi: 10.1016/j.abb.2009.08.015. Epub 2009 Aug 25. |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Glutathione, GSH (μmol/g Hb) | Change in GSH from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| Catalase (U/g Hb) | Change in catalase from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| Superoxide dismutase, SOD (U/g Hb) | Change in SOD from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| Glutathione peroxidase, GPx (U/g Hb) | Change in GPx from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| Glucose-6-phosphate dehydrogenase, G6PD (U/g Hb) | Change in G6PD from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| Uric acid (mM) | Change in uric acid from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| Albumin (μM) | Change in albumin from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| Bilirubin (μM) | Change in bilirubin from baseline (pre-exercise) at immediately after exercise and at day 2 and day 4 post-exercise |
| 22539728 | Background | Nikolaidis MG, Kyparos A, Spanou C, Paschalis V, Theodorou AA, Vrabas IS. Redox biology of exercise: an integrative and comparative consideration of some overlooked issues. J Exp Biol. 2012 May 15;215(Pt 10):1615-25. doi: 10.1242/jeb.067470. |
| 19997026 | Background | Theodorou AA, Nikolaidis MG, Paschalis V, Sakellariou GK, Fatouros IG, Koutedakis Y, Jamurtas AZ. Comparison between glucose-6-phosphate dehydrogenase-deficient and normal individuals after eccentric exercise. Med Sci Sports Exerc. 2010 Jun;42(6):1113-21. doi: 10.1249/MSS.0b013e3181c67ecd. |
| 22288788 | Background | Panayiotou G, Paschalis V, Nikolaidis MG, Theodorou AA, Deli CK, Fotopoulou N, Fatouros IG, Koutedakis Y, Sampanis M, Jamurtas AZ. No adverse effects of statins on muscle function and health-related parameters in the elderly: an exercise study. Scand J Med Sci Sports. 2013 Oct;23(5):556-67. doi: 10.1111/j.1600-0838.2011.01437.x. Epub 2012 Jan 31. |